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10.1038/ncomms9587 http://scihub22266oqcxt.onion/10.1038/ncomms9587 C4674671!4674671!26617050     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26617050|t=2015. A tunable artificial circadian clock in clock-defective mice |pdf=|usr=}}{{26617050}} gab.com Text A tunable artificial circadian clock in clock-defective mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26617050 #FOAvip Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for biological oscillators, but have limited similarity to physiological pathways. Here we report the generation of an artificial, mammalian circadian clock in vivo, capable of generating robust, tunable circadian rhythms. In mice deficient in Per1 and Per2 genes (thus lacking circadian rhythms), we artificially generate PER2 rhythms and restore circadian sleep/wake cycles with an inducible Per2 transgene. Our artificial clock is tunable as the period and phase of the rhythms can be modulated predictably. This feature, and other design principles of our work, might enhance the study and treatment of circadian dysfunction and broader aspects of physiology involving biological oscillators. Twit Text FOAVip A tunable artificial circadian clock in clock-defective mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26617050 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617050 #FOAvip English Wikipedia <ref>{{Cite pmid|26617050}}</ref> A tunable artificial circadian clock in clock-defective mice #MMPMID26617050 D'Alessandro M; Beesley S; Kim JK; Chen R; Abich E; Cheng W; Yi P; Takahashi JS; Lee C Nat Commun 2015[]; 6 (ä): ä PMID26617050show ga Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for biological oscillators, but have limited similarity to physiological pathways. Here we report the generation of an artificial, mammalian circadian clock in vivo, capable of generating robust, tunable circadian rhythms. In mice deficient in Per1 and Per2 genes (thus lacking circadian rhythms), we artificially generate PER2 rhythms and restore circadian sleep/wake cycles with an inducible Per2 transgene. Our artificial clock is tunable as the period and phase of the rhythms can be modulated predictably. This feature, and other design principles of our work, might enhance the study and treatment of circadian dysfunction and broader aspects of physiology involving biological oscillators. äA tunable artificial circadian clock in clock-defective mice (epmc).pdf DeepDyve Pubget Overpricing