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10.1038/ncomms10069 http://scihub22266oqcxt.onion/10.1038/ncomms10069 C4674669!4674669!26616563     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26616563|t=2015. Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci |pdf=|usr=}}{{26616563}} gab.com Text Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26616563 #FOAvip Genome-wide association studies have been tremendously successful in identifying genetic variants associated with complex diseases. The majority of association signals are intergenic and evidence is accumulating that a high proportion of signals lie in enhancer regions. We use Capture Hi-C to investigate, for the first time, the interactions between associated variants for four autoimmune diseases and their functional targets in B- and T-cell lines. Here we report numerous looping interactions and provide evidence that only a minority of interactions are common to both B- and T-cell lines, suggesting interactions may be highly cell-type specific; some disease-associated SNPs do not interact with the nearest gene but with more compelling candidate genes (for example, FOXO1, AZI2) often situated several megabases away; and finally, regions associated with different autoimmune diseases interact with each other and the same promoter suggesting common autoimmune gene targets (for example, PTPRC, DEXI and ZFP36L1). Twit Text FOAVip Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26616563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26616563 #FOAvip English Wikipedia <ref>{{Cite pmid|26616563}}</ref> Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci #MMPMID26616563 Martin P; McGovern A; Orozco G; Duffus K; Yarwood A; Schoenfelder S; Cooper NJ; Barton A; Wallace C; Fraser P; Worthington J; Eyre S Nat Commun 2015[]; 6 (ä): ä PMID26616563show ga Genome-wide association studies have been tremendously successful in identifying genetic variants associated with complex diseases. The majority of association signals are intergenic and evidence is accumulating that a high proportion of signals lie in enhancer regions. We use Capture Hi-C to investigate, for the first time, the interactions between associated variants for four autoimmune diseases and their functional targets in B- and T-cell lines. Here we report numerous looping interactions and provide evidence that only a minority of interactions are common to both B- and T-cell lines, suggesting interactions may be highly cell-type specific; some disease-associated SNPs do not interact with the nearest gene but with more compelling candidate genes (for example, FOXO1, AZI2) often situated several megabases away; and finally, regions associated with different autoimmune diseases interact with each other and the same promoter suggesting common autoimmune gene targets (for example, PTPRC, DEXI and ZFP36L1). äCapture Hi-C reveals novel candidate genes and complex long-range inte(epmc).pdf DeepDyve Pubget Overpricing