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10.1083/jcb.201404147 http://scihub22266oqcxt.onion/10.1083/jcb.201404147 C4674273!4674273 !26644517     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26644517 &cmd=llinks): Failed to open stream: HTTP request failed! 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A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity |pdf=|usr=}}{{26644517 }} gab.com Text A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26644517 #FOAvip Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with full penetrance. Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and KtyII(-/-)(K8) mice demonstrates that absence of KIF causes dysregulation of many CE constituents, including downregulation of desmoglein 1. Despite persistence of loricrin expression and upregulation of many Nrf2 targets, including CE components Sprr2d and Sprr2h, extensive barrier defects persist, identifying keratins as essential CE scaffolds. Furthermore, we show that KIFs control mitochondrial lipid composition and activity in a cell-intrinsic manner. Therefore, our study explains the complexity of keratinopathies accompanied by barrier disorders by linking keratin scaffolds to mitochondria, adhesion, and CE formation. Twit Text FOAVip A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26644517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26644517 #FOAvip English Wikipedia <ref>{{Cite pmid|26644517 }}</ref> A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity #MMPMID26644517 Kumar V ; Bouameur JE ; Bär J ; Rice RH ; Hornig-Do HT ; Roop DR ; Schwarz N ; Brodesser S ; Thiering S ; Leube RE ; Wiesner RJ ; Vijayaraj P ; Brazel CB ; Heller S ; Binder H ; Löffler-Wirth H ; Seibel P ; Magin TM J Cell Biol 2015[Dec]; 211 (5 ): 1057-75 PMID26644517 show ga Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with full penetrance. Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and KtyII(-/-)(K8) mice demonstrates that absence of KIF causes dysregulation of many CE constituents, including downregulation of desmoglein 1. Despite persistence of loricrin expression and upregulation of many Nrf2 targets, including CE components Sprr2d and Sprr2h, extensive barrier defects persist, identifying keratins as essential CE scaffolds. Furthermore, we show that KIFs control mitochondrial lipid composition and activity in a cell-intrinsic manner. Therefore, our study explains the complexity of keratinopathies accompanied by barrier disorders by linking keratin scaffolds to mitochondria, adhesion, and CE formation. |Animals [MESH] |Cell Adhesion [MESH] |Cell Membrane/metabolism [MESH] |Cornified Envelope Proline-Rich Proteins/metabolism [MESH] |DNA-Binding Proteins/metabolism [MESH] |Epidermis/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Developmental [MESH] |Genotype [MESH] |Intermediate Filaments/metabolism [MESH] |Keratinocytes/metabolism [MESH] |Keratins/*metabolism [MESH] |Lipids/*chemistry [MESH] |Male [MESH] |Membrane Proteins/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mitochondria/*metabolism [MESH] |Proteome/metabolism [MESH]A keratin scaffold regulates epidermal barrier formation, mitochondria(epmc).pdf DeepDyve Pubget Overpricing