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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Trop+Med+Hyg
2015 ; 93
(6
): 1364-1370
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Seroepidemiological Study of Interepidemic Rift Valley Fever Virus Infection
Among Persons with Intense Ruminant Exposure in Madagascar and Kenya
#MMPMID26458775
Gray GC
; Anderson BD
; LaBeaud AD
; Heraud JM
; Fèvre EM
; Andriamandimby SF
; Cook EAJ
; Dahir S
; de Glanville WA
; Heil GL
; Khan SU
; Muiruri S
; Olive MM
; Thomas LF
; Merrill HR
; Merrill MLM
; Richt JA
Am J Trop Med Hyg
2015[Dec]; 93
(6
): 1364-1370
PMID26458775
show ga
In this cross-sectional seroepidemiological study we sought to examine the
evidence for circulation of Rift Valley fever virus (RVFV) among herders in
Madagascar and Kenya. From July 2010 to June 2012, we enrolled 459 herders and 98
controls (without ruminant exposures) and studied their sera (immunoglobulin G
[IgG] and IgM through enzyme-linked immunosorbent assay [ELISA] and plaque
reduction neutralization test [PRNT] assays) for evidence of previous RVFV
infection. Overall, 59 (12.9%) of 459 herders and 7 (7.1%) of the 98 controls
were positive by the IgG ELISA assay. Of the 59 ELISA-positive herders, 23
(38.9%) were confirmed by the PRNT assay (21 from eastern Kenya). Two of the 21
PRNT-positive study subjects also had elevated IgM antibodies against RVFV
suggesting recent infection. Multivariate modeling in this study revealed that
being seminomadic (odds ratio [OR] = 6.4, 95% confidence interval [CI] =
2.1-15.4) was most strongly associated with antibodies against RVFV. Although we
cannot know when these infections occurred, it seems likely that some
interepidemic RVFV infections are occurring among herders. As there are
disincentives regarding reporting RVFV outbreaks in livestock or wildlife, it may
be prudent to conduct periodic, limited, active seroepidemiological surveillance
for RVFV infections in herders, especially in eastern Kenya.
|Adolescent
[MESH]
|Adult
[MESH]
|Animals
[MESH]
|Antibodies, Viral/immunology
[MESH]
|Enzyme-Linked Immunosorbent Assay
[MESH]
|Epidemics/statistics & numerical data
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Immunoglobulin M/immunology
[MESH]
|Kenya/epidemiology
[MESH]
|Madagascar/epidemiology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Neutralization Tests
[MESH]
|Rift Valley Fever/diagnosis/*epidemiology/etiology
[MESH]
|Rift Valley fever virus/immunology/physiology
[MESH]