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Outcome Comparisons Between Patients on Peritoneal Dialysis With and Without
Polycystic Kidney Disease: A Nationwide Matched Cohort Study
#MMPMID26632899
Yang JY
; Chen L
; Chao CT
; Peng YS
; Chiang CK
; Kao TW
; Chien KL
; Wu HY
; Huang JW
; Hung KY
Medicine (Baltimore)
2015[Dec]; 94
(48
): e2166
PMID26632899
show ga
Polycystic kidney disease (PCKD) is the most common hereditary cause of end-stage
renal disease. The complications associated with this disease may affect the
performance of peritoneal dialysis (PD). The aim of this study was to compare the
outcomes between patients on PD with PCKD and without PCKD.We extracted an
incident cohort of adult (? 20 years old) patients on long-term PD from the
Taiwan National Health Insurance Research Database. Patients with PCKD were
identified by specific diagnosis codes. We recorded baseline comorbidities,
socioeconomic status, timing of referral to a nephrologist, prior hemodialysis
history before PD, and the type of PD modalities. We compared the risk of death,
technique failure, peritonitis, hospitalization, and outpatient visiting as well
as overall medical expenditure between the patients with PCKD and a groups of
patients without PCKD who were propensity-score matched (1:3). The analysis was
carried out by various Cox regression models that considered competing risk and
time-varying coefficients. We enrolled 139 patients with PCKD and 7739 patients
without PCKD who started long-term PD between 1999 and 2010. Patients with PCKD
were less comorbid and more often treated with automated PD. In the
propensity-score matched analysis, both overall survival and technique survival
did not differ between the patients and the result was similar for
hospitalization and peritonitis after adjusting for the application of automated
PD. Furthermore, the overall annual medical expenditures were similar between the
patients with and without PCKD. PD patients with PCKD are comparable to PD
patients without PCKD in terms of risk of death, peritonitis, technique failure,
and hospitalization in the present study. Furthermore, the medical expenses of
the 2 groups after initiation of PD are also indistinguishable.
|Adult
[MESH]
|Age Factors
[MESH]
|Aged
[MESH]
|Cohort Studies
[MESH]
|Comorbidity
[MESH]
|Female
[MESH]
|Health Expenditures
[MESH]
|Hospitalization/statistics & numerical data
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Peritoneal Dialysis/economics/*statistics & numerical data
[MESH]
free
free
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