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10.1146/annurev-immunol-032414-112025 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032414-112025 C4674156!4674156 !25650177     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25650177 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Immunol 2015 ; 33 (ä): 505-38 Nephropedia Template TP {{tp|p=25650177 |t=2015. Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors |pdf=|usr=}}{{25650177 }} gab.com Text Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25650177 #FOAvip Mammalian lymphoid immunity is mediated by fast and slow responders to pathogens. Fast innate lymphocytes are active within hours after infections in mucosal tissues. Slow adaptive lymphocytes are conventional T and B cells with clonal antigen receptors that function days after pathogen exposure. A transcription factor (TF) regulatory network guiding early T cell development is at the core of effector function diversification in all innate lymphocytes, and the kinetics of immune responses is set by developmental programming. Operational units within the innate lymphoid system are not classified by the types of pathogen-sensing machineries but rather by discrete effector functions programmed by regulatory TF networks. Based on the evolutionary history of TFs of the regulatory networks, fast effectors likely arose earlier in the evolution of animals to fortify body barriers, and in mammals they often develop in fetal ontogeny prior to the establishment of fully competent adaptive immunity. Twit Text FOAVip Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25650177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25650177 #FOAvip English Wikipedia <ref>{{Cite pmid|25650177 }}</ref> Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors #MMPMID25650177 Kang J ; Malhotra N Annu Rev Immunol 2015[]; 33 (ä): 505-38 PMID25650177 show ga Mammalian lymphoid immunity is mediated by fast and slow responders to pathogens. Fast innate lymphocytes are active within hours after infections in mucosal tissues. Slow adaptive lymphocytes are conventional T and B cells with clonal antigen receptors that function days after pathogen exposure. A transcription factor (TF) regulatory network guiding early T cell development is at the core of effector function diversification in all innate lymphocytes, and the kinetics of immune responses is set by developmental programming. Operational units within the innate lymphoid system are not classified by the types of pathogen-sensing machineries but rather by discrete effector functions programmed by regulatory TF networks. Based on the evolutionary history of TFs of the regulatory networks, fast effectors likely arose earlier in the evolution of animals to fortify body barriers, and in mammals they often develop in fetal ontogeny prior to the establishment of fully competent adaptive immunity. |*Lymphopoiesis [MESH] |Animals [MESH] |Biological Evolution [MESH] |Humans [MESH] |Immunity [MESH] |Immunity, Innate/*physiology [MESH] |Lymphocytes/*immunology/*metabolism [MESH] |Protein Binding/immunology [MESH] |Signal Transduction [MESH]Transcription factor networks directing the development, function, and(epmc).pdf DeepDyve Pubget Overpricing