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Efficacy and safety of botulinum toxin type A for treatment of Frey s syndrome:
evidence from 22 published articles
#MMPMID26310612
Xie S
; Wang K
; Xu T
; Guo XS
; Shan XF
; Cai ZG
Cancer Med
2015[Nov]; 4
(11
): 1639-50
PMID26310612
show ga
Frey's syndrome (FS) is an unavoidable sequela following the surgery of the
parotid gland. Although several treatment methods are available, their efficacy
is short term or accompanied by unacceptable complications. In the past two
decades, botulinum toxin type A (BTXA) has been widely used to treat FS. Although
several systematic reviews have been reported recently, they were conflicting and
with obvious deficiencies. Thus, we performed an objectively systematic review to
determine whether BTXA is an effective and safe treatment for FS. A literature
retrieval covering PubMed, Web of Science, Ovid, Embase and Cochrane library was
performed on 16 January, 2015. Proportion meta-analysis and corresponding 95%
confidence interval (CI) were performed to evaluate the efficacy and safety of
BXTA in treatment of FS. A total of 499 records were retrieved and 22 articles
with 23 studies were included after scrutiny by two independent authors.
Statistical analyses regarding the effective rate, incidence of complications
were used to estimate the efficacy and safety of BTXA. Our results suggested that
the effective rate of BTXA for treatment of FS is 98.5% (95% CI = 0.971-0.994)
and the incidence of complication is 3.6% (95% CI = 0.017-0.061). In conclusion,
our study supports that BTXA produces meaningful benefits on the treatment of
patients with FS. However, owing to lack of strong evidence, future studies with
well-designed inclusion criteria and multicenter randomized controlled trials are
needed to give more credible evidence, if possible.
|Botulinum Toxins, Type A/administration & dosage/adverse effects/*therapeutic use
[MESH]
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