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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Iran+J+Pharm+Res
2015 ; 14
(4
): 1207-14
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Hypolipidemic, Hepatoprotective and Renoprotective Effects of Cydonia Oblonga
Mill Fruit in Streptozotocin-Induced Diabetic Rats
#MMPMID26664388
Mirmohammadlu M
; Hosseini SH
; Kamalinejad M
; Esmaeili Gavgani M
; Noubarani M
; Eskandari MR
Iran J Pharm Res
2015[Fal]; 14
(4
): 1207-14
PMID26664388
show ga
Diabetes mellitus is associated with complications in several different systems
of the body, and the incidence of diabetes is rapidly increasing worldwide. The
objective of the present study was to evaluate the effect of aqueous extract of
Cydonia oblonga Mill. Fruit on lipid profile and some biochemical parameters in
streptozotocin-induced diabetic rats. The extract showed anti hyper lipidemic
activity as evidenced by significant decreases in serum triglyceride, total
cholesterol, and low density lipoprotein cholesterol (LDL-C) levels along with
the elevation of high density lipoprotein cholesterol (HDL-C) in the diabetic
rats. The biochemical liver functional tests were also analyzed and it was shown
that serum biomarkers of liver dysfunction, including alanine transaminase (ALT),
aspartate transaminase (AST), and alkaline phosphatase (ALP) were significantly
reduced in aqueous extract of Cydonia oblonga Mill. treated diabetic rats. In
addition, our results showed that the oral administration of the extract
prevented diabetes-induced increase in serum urea and creatinine levels as the
markers of renal dysfunction. In conclusion, the present study indicates that
aqueous extract of Cydonia oblonga Mill. Is able to improve some of the symptoms
associated with diabetes and possesses hypolipidemic, hepatoprotective, and
renoprotective effects in streptozotocin-induced diabetic rats.