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10.14814/phy2.12600 http://scihub22266oqcxt.onion/10.14814/phy2.12600 C4673630!4673630 !26537344     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26537344 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Rep 2015 ; 3 (11 ): ä Nephropedia Template TP {{tp|p=26537344 |t=2015. Pseudohypoaldosteronism type 1 and Liddle s syndrome mutations that affect the single-channel properties of the epithelial Na+ channel |pdf=|usr=}}{{26537344 }} gab.com Text Pseudohypoaldosteronism type 1 and Liddle s syndrome mutations that affect the single-channel properties of the epithelial Na+ channel JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26537344 #FOAvip These studies test whether three disease-causing mutations in genes (SCNN1A and SCNN1G) encoding subunits of the epithelial Na(+) channel, ENaC, affect the biophysical and gating properties of this important renal ion channel. The S562P missense mutation in ?ENaC and the K106_S108delinsN mutation in ?ENaC are associated with pseudohypoaldosteronism type 1 (PHA1). The N530S missense mutation in ?ENaC causes Liddle's syndrome. Incorporation of S562P into ?ENaC and K106_S108N into ?ENaC resulted in significant decreases in macroscopic ENaC currents. Conversely, incorporation of N530S into ?ENaC increased macroscopic ENaC current. The S562P substitution resulted in a nonfunctional channel. The K106_S108N mutation produced a functional channel having a normal macroscopic current-voltage relation, there was a slight but significant decrease in unitary conductance and a marked decrease in single-channel open probability. The N530S substitution increased single-channel open probability having no effect on the macroscopic current-voltage relation or unitary conductance of the channel. These findings are consistent with mutation of residues at 562 in ?ENaC and 530 in ?ENaC, and a 3' splice site in SCNN1G (318-1 G?A; K106_108SdelinsN) resulting in aberrant ENaC activity due to changes in the biophysical and gating properties of the channel. Such changes likely contribute to the cellular mechanism underpinning the PHA1 and Liddle's syndrome caused by these mutations in ENaC subunits. Twit Text FOAVip Pseudohypoaldosteronism type 1 and Liddle s syndrome mutations that affect the single-channel properties of the epithelial Na+ channel ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26537344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26537344 #FOAvip English Wikipedia <ref>{{Cite pmid|26537344 }}</ref> Pseudohypoaldosteronism type 1 and Liddle s syndrome mutations that affect the single-channel properties of the epithelial Na+ channel #MMPMID26537344 Boiko N ; Kucher V ; Stockand JD Physiol Rep 2015[Nov]; 3 (11 ): ä PMID26537344 show ga These studies test whether three disease-causing mutations in genes (SCNN1A and SCNN1G) encoding subunits of the epithelial Na(+) channel, ENaC, affect the biophysical and gating properties of this important renal ion channel. The S562P missense mutation in ?ENaC and the K106_S108delinsN mutation in ?ENaC are associated with pseudohypoaldosteronism type 1 (PHA1). The N530S missense mutation in ?ENaC causes Liddle's syndrome. Incorporation of S562P into ?ENaC and K106_S108N into ?ENaC resulted in significant decreases in macroscopic ENaC currents. Conversely, incorporation of N530S into ?ENaC increased macroscopic ENaC current. The S562P substitution resulted in a nonfunctional channel. The K106_S108N mutation produced a functional channel having a normal macroscopic current-voltage relation, there was a slight but significant decrease in unitary conductance and a marked decrease in single-channel open probability. The N530S substitution increased single-channel open probability having no effect on the macroscopic current-voltage relation or unitary conductance of the channel. These findings are consistent with mutation of residues at 562 in ?ENaC and 530 in ?ENaC, and a 3' splice site in SCNN1G (318-1 G?A; K106_108SdelinsN) resulting in aberrant ENaC activity due to changes in the biophysical and gating properties of the channel. Such changes likely contribute to the cellular mechanism underpinning the PHA1 and Liddle's syndrome caused by these mutations in ENaC subunits. äPseudohypoaldosteronism type 1 and Liddle s syndrome mutations that af(epmc).pdf DeepDyve Pubget Overpricing