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10.14814/phy2.12544 http://scihub22266oqcxt.onion/10.14814/phy2.12544 C4673620!4673620!26537340     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26537340&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2015 ; 3 (11): ä Nephropedia Template TP {{tp|p=26537340|t=2015. Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis |pdf=|usr=}}{{26537340}} gab.com Text Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26537340 #FOAvip The Notch signaling pathway is required to maintain renin expression within juxtaglomerular (JG) cells. However, the specific ligand which activates Notch signaling in renin-expressing cells remains undefined. In this study, we found that among all Notch ligands, Jagged1 is differentially expressed in renin cells with higher expression during neonatal life. We therefore hypothesized that Jagged1 was involved in renin expression and/or vascular integrity. We used a conditional knockout approach to delete Jagged1 in cells of the renin lineage. Deletion of Jagged1 specifically within renin cells did not result in decreased renin production within the kidney. However, animals with conditional deletion of Jagged1 did develop focal kidney fibrosis and elevated blood urea nitrogen. Our data demonstrate that Jagged1-mediated Notch signaling is dispensable in renin cells of the kidney in regard to renin expression. However, deletion of Jagged1 in renin cells descendants affects perivascular?interstitial integrity leading to focal fibrosis and diminished renal function. Twit Text FOAVip Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26537340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26537340 #FOAvip English Wikipedia <ref>{{Cite pmid|26537340}}</ref> Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis #MMPMID26537340 Belyea BC; Xu F; Sequeira-Lopez MLS; Ariel Gomez R Physiol Rep 2015[Nov]; 3 (11): ä PMID26537340show ga The Notch signaling pathway is required to maintain renin expression within juxtaglomerular (JG) cells. However, the specific ligand which activates Notch signaling in renin-expressing cells remains undefined. In this study, we found that among all Notch ligands, Jagged1 is differentially expressed in renin cells with higher expression during neonatal life. We therefore hypothesized that Jagged1 was involved in renin expression and/or vascular integrity. We used a conditional knockout approach to delete Jagged1 in cells of the renin lineage. Deletion of Jagged1 specifically within renin cells did not result in decreased renin production within the kidney. However, animals with conditional deletion of Jagged1 did develop focal kidney fibrosis and elevated blood urea nitrogen. Our data demonstrate that Jagged1-mediated Notch signaling is dispensable in renin cells of the kidney in regard to renin expression. However, deletion of Jagged1 in renin cells descendants affects perivascular?interstitial integrity leading to focal fibrosis and diminished renal function. äLoss of Jagged1 in renin progenitors leads to focal kidney fibrosis (epmc).pdf DeepDyve Pubget Overpricing