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10.3109/10409238.2015.1028612 http://scihub22266oqcxt.onion/10.3109/10409238.2015.1028612 C4673589!4673589!25837229     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Rev+Biochem+Mol+Biol 2015 ; 50 (4): 284-97 Nephropedia Template TP {{tp|p=25837229|t=2015. The human NAD metabolome: Functions, metabolism and compartmentalization |pdf=|usr=}}{{25837229}} gab.com Text The human NAD metabolome: Functions, metabolism and compartmentalization JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25837229 #FOAvip The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events. In humans, NAD is synthesized from vitamin B3 precursors, most prominently from nicotinamide, which is the degradation product of all NAD-dependent signaling reactions. The scope of NAD-mediated regulatory processes is wide including enzyme regulation, control of gene expression and health span, DNA repair, cell cycle regulation and calcium signaling. In these processes, nicotinamide is cleaved from NAD+ and the remaining ADP-ribosyl moiety used to modify proteins (deacetylation by sirtuins or ADP-ribosylation) or to generate calcium-mobilizing agents such as cyclic ADP-ribose. This review will also emphasize the role of the intermediates in the NAD metabolome, their intra- and extra-cellular conversions and potential contributions to subcellular compartmentalization of NAD pools. Twit Text FOAVip The human NAD metabolome: Functions, metabolism and compartmentalization ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25837229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25837229 #FOAvip English Wikipedia <ref>{{Cite pmid|25837229}}</ref> The human NAD metabolome: Functions, metabolism and compartmentalization #MMPMID25837229 Nikiforov A; Kulikova V; Ziegler M Crit Rev Biochem Mol Biol 2015[Jul]; 50 (4): 284-97 PMID25837229show ga The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events. In humans, NAD is synthesized from vitamin B3 precursors, most prominently from nicotinamide, which is the degradation product of all NAD-dependent signaling reactions. The scope of NAD-mediated regulatory processes is wide including enzyme regulation, control of gene expression and health span, DNA repair, cell cycle regulation and calcium signaling. In these processes, nicotinamide is cleaved from NAD+ and the remaining ADP-ribosyl moiety used to modify proteins (deacetylation by sirtuins or ADP-ribosylation) or to generate calcium-mobilizing agents such as cyclic ADP-ribose. This review will also emphasize the role of the intermediates in the NAD metabolome, their intra- and extra-cellular conversions and potential contributions to subcellular compartmentalization of NAD pools. äThe human NAD metabolome: Functions, metabolism and compartmentalizati(epmc).pdf DeepDyve Pubget Overpricing