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10.3109/13506129.2015.1015678 http://scihub22266oqcxt.onion/10.3109/13506129.2015.1015678 C4673564!4673564 !26096568     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26096568 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Amyloid 2015 ; 22 (2 ): 117-22 Nephropedia Template TP {{tp|p=26096568 |t=2015. Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases |pdf=|usr=}}{{26096568 }} gab.com Text Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases JO: Amyloid http://www.kidney.de/pget.php?&tw=1&pmid=26096568 #FOAvip PURPOSE: Assessment of ocular involvement in transthyretin-related familial amyloidosis with polyneuropathy (FAP) in a large cohort of Portuguese patients. METHODS: We reviewed the medical records of 513 Portuguese FAP mutation carriers, at the Ophthalmology Service, Centro Hospitalar do Porto, between 1 January 2008 and 31 January 2013. Abnormal conjunctiva vessels (ACV), Schirmer test, tear break-up time (TBUT), amyloid deposition on the iris (DAI), scalloped iris, amyloid deposition on the anterior capsule of the lens (DAL), vitreous amyloidosis, retinal amyloid angiopathy and glaucoma were evaluated and registered. RESULTS: Of the 513 carriers, 477 (93%) had clinical systemic disease with a median duration of 9.3 (5.1-13.7) years and 247 were men. Of these, 343 (72%) had been liver transplanted, on median of 6.6 (3.3-10.8) years before inclusion in this study. No ocular abnormalities were identified in the asymptomatic carriers (7%). The abnormalities observed with decreasing frequency were abnormal TBUT (379 patients, 79.5%, 751 eyes), abnormal Schirmer test (320 patients, 67%, 635 eyes), DAI (183 patients, 38.4%, 350 eyes), DAL (157 patients, 32.9%, 308 eyes), scalloped iris (133 patients, 27.9%, 238 eyes), glaucoma (97 patients, 20%, 165 eyes), vitreous amyloidosis (83 patients, 17.4%, 139 eyes), ACV (68 patients, 14%, 136 eyes) and amyloidotic retinal angiopathy (21 patients, 4%, 32 eyes). Patients with abnormal Schirmer test (p?<?0.001), scalloped iris (p?=?0.006) and vitreous amyloidosis (p?=?0.007) were significantly older than the others. According to their age of onset of systemic disease, the patients have been split into early-onset (<40 years old), intermediate-onset (40-50 years old), late onset (>50 years old) and asymptomatic carriers. We observed a statistically significant difference in the prevalence of ACV (p?=?0.045) and of an abnormal Schirmer test (p?=?0.004) between groups. Transplanted patients have a significantly higher prevalence of DAI (p?=?0.001), DAL (p?=?0.009) and vitreous amyloidosis (p?=?0.025) than non-transplanted patients. Of the 165 eyes with glaucoma, 92.1% had scalloped iris (p?<?0.001) and of 32 eyes with retinal amyloidotic angiopathy, 68.8% had vitreous amyloidosis (p?<?0.001). All prevalences increased with time of disease. The earliest ocular manifestations were abnormal Schirmer test and abnormal TBUT (12% and 17% at 5 years of clinical disease) and the least prevalent was retinal amyloid angiopathy (8% at 15 years of clinical disease). CONCLUSION: Ocular disorders in FAP patients are common, and their prevalence increases with disease duration. Prevalence is influenced by several factors, such as the age at onset of FAP and liver transplantation. Twit Text FOAVip Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases ????Amyloid http://www.kidney.de/pget.php?&tw=1&pmid=26096568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26096568 #FOAvip English Wikipedia <ref>{{Cite pmid|26096568 }}</ref> Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases #MMPMID26096568 Beirão JM ; Malheiro J ; Lemos C ; Beirão I ; Costa P ; Torres P Amyloid 2015[]; 22 (2 ): 117-22 PMID26096568 show ga PURPOSE: Assessment of ocular involvement in transthyretin-related familial amyloidosis with polyneuropathy (FAP) in a large cohort of Portuguese patients. METHODS: We reviewed the medical records of 513 Portuguese FAP mutation carriers, at the Ophthalmology Service, Centro Hospitalar do Porto, between 1 January 2008 and 31 January 2013. Abnormal conjunctiva vessels (ACV), Schirmer test, tear break-up time (TBUT), amyloid deposition on the iris (DAI), scalloped iris, amyloid deposition on the anterior capsule of the lens (DAL), vitreous amyloidosis, retinal amyloid angiopathy and glaucoma were evaluated and registered. RESULTS: Of the 513 carriers, 477 (93%) had clinical systemic disease with a median duration of 9.3 (5.1-13.7) years and 247 were men. Of these, 343 (72%) had been liver transplanted, on median of 6.6 (3.3-10.8) years before inclusion in this study. No ocular abnormalities were identified in the asymptomatic carriers (7%). The abnormalities observed with decreasing frequency were abnormal TBUT (379 patients, 79.5%, 751 eyes), abnormal Schirmer test (320 patients, 67%, 635 eyes), DAI (183 patients, 38.4%, 350 eyes), DAL (157 patients, 32.9%, 308 eyes), scalloped iris (133 patients, 27.9%, 238 eyes), glaucoma (97 patients, 20%, 165 eyes), vitreous amyloidosis (83 patients, 17.4%, 139 eyes), ACV (68 patients, 14%, 136 eyes) and amyloidotic retinal angiopathy (21 patients, 4%, 32 eyes). Patients with abnormal Schirmer test (p?50 years old) and asymptomatic carriers. We observed a statistically significant difference in the prevalence of ACV (p?=?0.045) and of an abnormal Schirmer test (p?=?0.004) between groups. Transplanted patients have a significantly higher prevalence of DAI (p?=?0.001), DAL (p?=?0.009) and vitreous amyloidosis (p?=?0.025) than non-transplanted patients. Of the 165 eyes with glaucoma, 92.1% had scalloped iris (p? |Adult [MESH] |Amyloid Neuropathies, Familial/epidemiology/*genetics/pathology [MESH] |Cross-Sectional Studies [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Mutation/genetics [MESH] |Portugal/epidemiology [MESH] |Prealbumin/*genetics [MESH]Ophthalmological manifestations in hereditary transthyretin (ATTR V30M(epmc).pdf DeepDyve Pubget Overpricing