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10.1038/srep17851 http://scihub22266oqcxt.onion/10.1038/srep17851 C4673454!4673454!26647819     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26647819|t=2015. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia |pdf=|usr=}}{{26647819}} gab.com Text REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26647819 #FOAvip The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, the degree and duration of HIF-1? expression in hypoxia must be carefully balanced within cells in order to avoid unwanted side effects associated with excessive activity. The expression of HIF-1? mRNA is suppressed in prolonged hypoxia, suggesting that the control of HIF1A gene transcription is tightly regulated by negative feedback mechanisms. Little is known about the resolution of the HIF-1? protein response and the suppression of HIF-1? mRNA in prolonged hypoxia. Here, we demonstrate that the Repressor Element 1-Silencing Transcription factor (REST) binds to the HIF-1? promoter in a hypoxia-dependent manner. Knockdown of REST using RNAi increases the expression of HIF-1? mRNA, protein and transcriptional activity. Furthermore REST knockdown increases glucose consumption and lactate production in a HIF-1?- (but not HIF-2?-) dependent manner. Finally, REST promotes the resolution of HIF-1? protein expression in prolonged hypoxia. In conclusion, we hypothesize that REST represses transcription of HIF-1? in prolonged hypoxia, thus contributing to the resolution of the HIF-1? response. Twit Text FOAVip REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26647819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26647819 #FOAvip English Wikipedia <ref>{{Cite pmid|26647819}}</ref> REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia #MMPMID26647819 Cavadas MAS; Mesnieres M; Crifo B; Manresa MC; Selfridge AC; Scholz CC; Cummins EP; Cheong A; Taylor CT Sci Rep 2015[]; 5 (ä): ä PMID26647819show ga The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, the degree and duration of HIF-1? expression in hypoxia must be carefully balanced within cells in order to avoid unwanted side effects associated with excessive activity. The expression of HIF-1? mRNA is suppressed in prolonged hypoxia, suggesting that the control of HIF1A gene transcription is tightly regulated by negative feedback mechanisms. Little is known about the resolution of the HIF-1? protein response and the suppression of HIF-1? mRNA in prolonged hypoxia. Here, we demonstrate that the Repressor Element 1-Silencing Transcription factor (REST) binds to the HIF-1? promoter in a hypoxia-dependent manner. Knockdown of REST using RNAi increases the expression of HIF-1? mRNA, protein and transcriptional activity. Furthermore REST knockdown increases glucose consumption and lactate production in a HIF-1?- (but not HIF-2?-) dependent manner. Finally, REST promotes the resolution of HIF-1? protein expression in prolonged hypoxia. In conclusion, we hypothesize that REST represses transcription of HIF-1? in prolonged hypoxia, thus contributing to the resolution of the HIF-1? response. äREST mediates resolution of HIF-dependent gene expression in prolonged(epmc).pdf DeepDyve Pubget Overpricing