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10.14348/molcells.2015.0197 http://scihub22266oqcxt.onion/10.14348/molcells.2015.0197 C4673414!4673414!26537190     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cells 2015 ; 38 (11): 991-7 Nephropedia Template TP {{tp|p=26537190|t=2015. Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin |pdf=|usr=}}{{26537190}} gab.com Text Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=26537190 #FOAvip Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4?-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3? untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas. Twit Text FOAVip Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=26537190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26537190 #FOAvip English Wikipedia <ref>{{Cite pmid|26537190}}</ref> Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin #MMPMID26537190 Ryu J; Yoon NA; Seong H; Jeong JY; Kang S; Park N; Choi J; Lee DH; Roh GS; Kim HJ; Cho GJ; Choi WS; Park JY; Park JW; Kang SS Mol Cells 2015[Nov]; 38 (11): 991-7 PMID26537190show ga Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4?-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3? untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas. äResveratrol Induces Glioma Cell Apoptosis through Activation of Triste(epmc).pdf DeepDyve Pubget Overpricing