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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mediators+Inflamm 2015 ; 2015 (ä): ä Nephropedia Template TP
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Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections #MMPMID26688618
Bryan AM; Del Poeta M; Luberto C
Mediators Inflamm 2015[]; 2015 (ä): ä PMID26688618show ga
Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function and the role of macrophages and neutrophils in the most common types of fungal infections, as well as studies that have linked these three concepts to show the importance of sphingolipid signaling in immune response to fungal infections.