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2015 ; 2015
(ä): 565760
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Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2
Cytokines and Promoting M2 Macrophages Polarization
#MMPMID26688684
Zhang Y
; Yang P
; Cui R
; Zhang M
; Li H
; Qian C
; Sheng C
; Qu S
; Bu L
Int J Endocrinol
2015[]; 2015
(ä): 565760
PMID26688684
show ga
Obesity is now recognized as a low-grade, chronic inflammatory disease that is
linked to a myriad of disorders including cardiovascular diseases, type 2
diabetes, and liver diseases. Recently it is found that eosinophils accelerate
alternative activation macrophage (AAM) polarization by secreting Th2 type
cytokines such as interleukin-4 and interleukin-13, thereby reducing
metainflammation in adipose tissue. In this review, we focused on the role of
eosinophils in regulating metabolic homeostasis and obesity.