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2015 ; 2015
(ä): 910352
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
A Systematic Review of Peripheral and Central Nervous System Involvement of
Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren s Syndrome,
and Associated Immunological Profiles
#MMPMID26688829
Bougea A
; Anagnostou E
; Konstantinos G
; George P
; Triantafyllou N
; Kararizou E
Int J Chronic Dis
2015[]; 2015
(ä): 910352
PMID26688829
show ga
Both central (CNS) and peripheral nervous system (PNS) complications are frequent
and varied in connective tissue diseases. A systematic review was conducted
between 1989 and 2014 in the databases Medline, Scopus, and Cochrane Library
using the search terms, peripheral and central nervous complications and
immunological profiles, to identify studies in specific connective tissue
disorders such as rheumatoid arthritis, systemic lupus erythematosus, and primary
Sjögren's syndrome. A total of 675 references were identified, of which 118 were
selected for detailed analysis and 22 were included in the final review with a
total of 2338 participants. Our search focused only on studies upon connective
tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus, and
primary Sjögren's syndrome associated with seroimmunological data. The reported
prevalence of CNS involvement ranges from 9 to 92% across the reported studies.
However, the association between CNS and PNS manifestations and seroimmunological
profiles remains controversial. ?o date, no laboratory test has been shown as
pathognomonic neither for CNS nor for PNS involvement.