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By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated
metastatic ability in prostate cancer
#MMPMID26110567
Wen YC
; Lee WJ
; Tan P
; Yang SF
; Hsiao M
; Lee LM
; Chien MH
Oncotarget
2015[Aug]; 6
(25
): 21120-36
PMID26110567
show ga
Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a
bioactive coumarin derivative extracted from medicinal plants, inhibited
migration, invasion, epithelial to mesenchymal transition (EMT) in
androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC
in vivo. In patients, high Snail levels were correlated with a higher
histological Gleason sum and poor survival rates. Osthole inhibited the
TGF-?/Akt/MAPK pathways, reduced Snail-DNA-binding activity and induced
E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p
suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin
expression, and relieved the motility suppression caused by osthole treatment.
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