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10.18632/oncotarget.4229 http://scihub22266oqcxt.onion/10.18632/oncotarget.4229 C4673254!4673254 !26110567     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26110567 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (25 ): 21120-36 Nephropedia Template TP {{tp|p=26110567 |t=2015. By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer |pdf=|usr=}}{{26110567 }} gab.com Text By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26110567 #FOAvip Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-?/Akt/MAPK pathways, reduced Snail-DNA-binding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment. Twit Text FOAVip By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26110567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26110567 #FOAvip English Wikipedia <ref>{{Cite pmid|26110567 }}</ref> By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer #MMPMID26110567 Wen YC ; Lee WJ ; Tan P ; Yang SF ; Hsiao M ; Lee LM ; Chien MH Oncotarget 2015[Aug]; 6 (25 ): 21120-36 PMID26110567 show ga Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-?/Akt/MAPK pathways, reduced Snail-DNA-binding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment. |*Signal Transduction [MESH] |3' Untranslated Regions [MESH] |Animals [MESH] |Cadherins/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cell Survival [MESH] |Coumarins/*chemistry [MESH] |Disease Progression [MESH] |Down-Regulation [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Genes, Reporter [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, SCID [MESH] |MicroRNAs/antagonists & inhibitors/*metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Transplantation [MESH] |Prostatic Neoplasms/drug therapy/*metabolism/pathology [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/antagonists & inhibitors/*metabolism [MESH]By inhibiting snail signaling and miR-23a-3p, osthole suppresses the E(epmc).pdf DeepDyve Pubget Overpricing