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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(12
): e0144277
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography
Features in Various Anatomic Sites
#MMPMID26646242
Xing GS
; Wang S
; Sun YM
; Yuan Z
; Zhao XM
; Zhou CW
PLoS One
2015[]; 10
(12
): e0144277
PMID26646242
show ga
Gastrointestinal stromal tumors (GISTs) can present with different clinical and
immunohistochemical characteristics according to different anatomic sites. The
aim of this study was to compare clinicopathologic and computed tomography (CT)
features of small bowel stromal tumors located in the duodenum, jejunum, and
ileum. In total, 197 patients (109 male, 88 female) with small bowel GISTs were
retrospectively reviewed. All tumors had definite anatomic sites in the small
bowel tract with surgical confirmation. The clinicopathologic variables included
age, sex, onset of symptoms, and tumor risk category. CT variables included tumor
size, degree enhancement, enhancement pattern (region of necrosis), adjacent
tissue involvement, lymphadenopathy, and distant metastasis. We assessed any
possible differences according to different GIST site of origin. Based on tumor
size and mitotic count, the risk categories in different anatomic sites did not
differ significantly between duodenal and jejunal GISTs. However, high risk ileum
GISTs accounted for 66.0% of ileal cases, which was higher than duodenum cases
(36.8%, P = 0.002) and jejunum cases (43.9%, P = 0.004). The mean size of GISTs
in the ileum was 9.77 cm, which was significantly larger than in the duodenum
(7.41 cm, P = 0.043), and in the jejunum (8.14 cm, P = 0.027). On CT images,
enhancement degree appeared to gradually increase from the duodenum to the ileum
in the portal phase, and the enhancement pattern presented a tendency for
heterogeneity. In Conclusions, the clinicopathologic and CT features of small
bowel GISTs can differ according to different primary anatomic sites.