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2015 ; 14
(ä): 492
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Modelling optimum use of attractive toxic sugar bait stations for effective
malaria vector control in Africa
#MMPMID26643110
Zhu L
; Marshall JM
; Qualls WA
; Schlein Y
; McManus JW
; Arheart KL
; Hlaing WM
; Traore SF
; Doumbia S
; Müller GC
; Beier JC
Malar J
2015[Dec]; 14
(ä): 492
PMID26643110
show ga
BACKGROUND: The development of insecticide resistance and the increased
outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor
vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting
the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising
supplement to indoor tools. The number and configuration of these ATSB stations
needed for malaria control in a community needs to be determined. METHODS: A
hypothetical village, typical of those in sub-Saharan Africa, 600 × 600 m,
consisting of houses, humans and essential resource requirements of Anopheles
gambiae (sugar sources, outdoor resting sites, larval habitats) was simulated in
a spatial individual-based model. Resource-rich and resource-poor environments
were simulated separately. Eight types of configurations and different densities
of ATSB stations were tested. Anopheles gambiae population size, human biting
rate (HBR) and entomological inoculation rates (EIR) were compared between
different ATSB configurations and densities. Each simulated scenario was run 50
times. RESULTS: Compared to the outcomes not altered by ATSB treatment in the
control scenario, in resource-rich and resource-poor environments, respectively,
the optimum ATSB treatment reduced female abundance by 98.22 and 91.80 %, reduced
HBR by 99.52 and 98.15 %, and reduced EIR by 99.99 and 100 %. In resource-rich
environments, n × n grid design, stations at sugar sources, resting sites, larval
habitats, and random locations worked better in reducing vector population and
HBRs than other configurations (P < 0.0001). However, there was no significant
difference of EIR reductions between all ATSB configurations (P > 0.05). In
resource-poor environments, there was no significant difference of female
abundances, HBRs and EIRs between all ATSB configurations (P > 0.05). The optimum
number of ATSB stations was about 25 for resource-rich environments and nine for
resource-poor environments. CONCLUSIONS: ATSB treatment reduced An. gambiae
population substantially and reduced EIR to near zero regardless of environmental
resource availability. In resource-rich environments, dispersive configurations
worked better in reducing vector population, and stations at or around houses
worked better in preventing biting and parasite transmission. In resource-poor
environments, all configurations worked similarly. Optimum numbers of bait
stations should be adjusted according to seasonality when resource availability
changes.