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10.3389/fcvm.2015.00020 http://scihub22266oqcxt.onion/10.3389/fcvm.2015.00020 C4671354!4671354!26664892     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cardiovasc+Med 2015 ; 2 (ä): ä Nephropedia Template TP {{tp|p=26664892|t=2015. Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |pdf=|usr=}}{{26664892}} gab.com Text Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia JO: Front Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=26664892 #FOAvip The maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose four pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregnancy leads to an excessive innate immune response resulting in widespread inflammation, placental and renal dysfunction, vasoconstriction, and PE. Placental dysfunction due to shallow trophoblast invasion, inadequate spiral artery remodeling, and/or low placental perfusion initiates an innate immune response leading to excessive inflammation, endothelial and renal dysfunction, and PE. A heightened innate immune system due to pre-existing or acquired infections plus the presence of a paternally derived placenta and semi-allogeneic fetus cause an excessive innate immune response which manifests as PE. Lastly, an abnormal and excessive maternal immune response to pregnancy leads to widespread inflammation, organ dysfunction, and PE. We discuss the potential role of innate immunity in each of these scenarios, as well as the overlap, and how targeting the innate immune system might lead to therapies for the treatment of PE. Twit Text FOAVip Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia ????Front Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=26664892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26664892 #FOAvip English Wikipedia <ref>{{Cite pmid|26664892}}</ref> Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia #MMPMID26664892 Bounds KR; Newell-Rogers MK; Mitchell BM Front Cardiovasc Med 2015[]; 2 (ä): ä PMID26664892show ga The maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose four pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregnancy leads to an excessive innate immune response resulting in widespread inflammation, placental and renal dysfunction, vasoconstriction, and PE. Placental dysfunction due to shallow trophoblast invasion, inadequate spiral artery remodeling, and/or low placental perfusion initiates an innate immune response leading to excessive inflammation, endothelial and renal dysfunction, and PE. A heightened innate immune system due to pre-existing or acquired infections plus the presence of a paternally derived placenta and semi-allogeneic fetus cause an excessive innate immune response which manifests as PE. Lastly, an abnormal and excessive maternal immune response to pregnancy leads to widespread inflammation, organ dysfunction, and PE. We discuss the potential role of innate immunity in each of these scenarios, as well as the overlap, and how targeting the innate immune system might lead to therapies for the treatment of PE. äFour Pathways Involving Innate Immunity in the Pathogenesis of Preecla(epmc).pdf DeepDyve Pubget Overpricing