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10.1002/wrna.1276 http://scihub22266oqcxt.onion/10.1002/wrna.1276 C4671264!4671264!25630614     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Wiley+Interdiscip+Rev+RNA 2015 ; 6 (3): 311-26 Nephropedia Template TP {{tp|p=25630614|t=2015. Functional roles of alternative splicing factors in human disease |pdf=|usr=}}{{25630614}} gab.com Text Functional roles of alternative splicing factors in human disease JO: Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=25630614 #FOAvip Alternative splicing (AS) is an important mechanism used to generate greater transcriptomic and proteomic diversity from a finite genome. Nearly all human gene transcripts are alternatively spliced and can produce protein isoforms with divergent and even antagonistic properties that impact cell functions. Many AS events are tightly regulated in a cell-type or tissue-specific manner, and at different developmental stages. AS is regulated by RNA-binding proteins, including cell- or tissue-specific splicing factors. In the past few years, technological advances have defined genome-wide programs of AS regulated by increasing numbers of splicing factors. These splicing regulatory networks (SRNs) consist of transcripts that encode proteins that function in coordinated and related processes that impact the development and phenotypes of different cell types. As such, it is increasingly recognized that disruption of normal programs of splicing regulated by different splicing factors can lead to human diseases. We will summarize examples of diseases in which altered expression or function of splicing regulatory proteins has been implicated in human disease pathophysiology. As the role of AS continues to be unveiled in human disease and disease risk, it is hoped that further investigations into the functions of numerous splicing factors and their regulated targets will enable the development of novel therapies that are directed at specific AS events as well as the biological pathways they impact. WIREs RNA 2015, 6:311?326. doi: 10.1002/wrna.1276For further resources related to this article, please visit the http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1276WIREs website.Conflict of interest: The authors have declared no conflicts of interest for this article. Twit Text FOAVip Functional roles of alternative splicing factors in human disease ????Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=25630614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25630614 #FOAvip English Wikipedia <ref>{{Cite pmid|25630614}}</ref> Functional roles of alternative splicing factors in human disease #MMPMID25630614 Cieply B; Carstens RP Wiley Interdiscip Rev RNA 2015[May]; 6 (3): 311-26 PMID25630614show ga Alternative splicing (AS) is an important mechanism used to generate greater transcriptomic and proteomic diversity from a finite genome. Nearly all human gene transcripts are alternatively spliced and can produce protein isoforms with divergent and even antagonistic properties that impact cell functions. Many AS events are tightly regulated in a cell-type or tissue-specific manner, and at different developmental stages. AS is regulated by RNA-binding proteins, including cell- or tissue-specific splicing factors. In the past few years, technological advances have defined genome-wide programs of AS regulated by increasing numbers of splicing factors. These splicing regulatory networks (SRNs) consist of transcripts that encode proteins that function in coordinated and related processes that impact the development and phenotypes of different cell types. As such, it is increasingly recognized that disruption of normal programs of splicing regulated by different splicing factors can lead to human diseases. We will summarize examples of diseases in which altered expression or function of splicing regulatory proteins has been implicated in human disease pathophysiology. As the role of AS continues to be unveiled in human disease and disease risk, it is hoped that further investigations into the functions of numerous splicing factors and their regulated targets will enable the development of novel therapies that are directed at specific AS events as well as the biological pathways they impact. WIREs RNA 2015, 6:311?326. doi: 10.1002/wrna.1276For further resources related to this article, please visit the http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1276WIREs website.Conflict of interest: The authors have declared no conflicts of interest for this article. äFunctional roles of alternative splicing factors in human disease (epmc).pdf DeepDyve Pubget Overpricing