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10.1002/bies.201400191 http://scihub22266oqcxt.onion/10.1002/bies.201400191 C4671252!4671252!25683051     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioessays 2015 ; 37 (4): 379-88 Nephropedia Template TP {{tp|p=25683051|t=2015. Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery |pdf=|usr=}}{{25683051}} gab.com Text Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25683051 #FOAvip Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects are mRNA based. It explores several issues confounding miRNA target detection, and discusses their impact on the dominance of ?miRNA seed? dogma and the exploration of non-canonical binding sites. Finally, it makes comparisons between miRNA target prediction and transcription factor binding prediction, and questions the value of characterizing miRNA binding sites based on which miRNA nucleotides are paired with an mRNA. Twit Text FOAVip Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25683051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25683051 #FOAvip English Wikipedia <ref>{{Cite pmid|25683051}}</ref> Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery #MMPMID25683051 Cloonan N Bioessays 2015[Apr]; 37 (4): 379-88 PMID25683051show ga Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects are mRNA based. It explores several issues confounding miRNA target detection, and discusses their impact on the dominance of ?miRNA seed? dogma and the exploration of non-canonical binding sites. Finally, it makes comparisons between miRNA target prediction and transcription factor binding prediction, and questions the value of characterizing miRNA binding sites based on which miRNA nucleotides are paired with an mRNA. äRe-thinking miRNA-mRNA interactions: Intertwining issues confound targ(epmc).pdf DeepDyve Pubget Overpricing