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10.1038/srep17948 http://scihub22266oqcxt.onion/10.1038/srep17948 C4671150!4671150!26639755     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26639755|t=2015. PDGFR? plays a crucial role in connective tissue remodeling |pdf=|usr=}}{{26639755}} gab.com Text PDGFR plays a crucial role in connective tissue remodeling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26639755 #FOAvip Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-? (PDGFR?) in this process. In the present study, the Pdgfra gene was systemically inactivated in adult mouse (?-KO mouse), and the role of PDGFR? was examined in the subcutaneously implanted sponge matrices. PDGFR? expressed in the fibroblasts of Pdgfra-preserving control mice (Flox mice), was significantly reduced in the sponges in ?-KO mice. Neovascularized areas were largely suppressed in the ?-KO mice than in the Flox mice, whereas the other parameters related to the blood vessels and endothelial cells were similar. The deposition of collagen and fibronectin and the expression of collagen 1a1 and 3a1 genes were significantly reduced in ?-KO mice. There was a significantly decrease in the number and dividing fibroblasts in the ?-KO mice, and those of macrophages were similar between the two genotypes. Hepatocyte growth factor (Hgf) gene expression was suppressed in Pdgfra-inactivated fibroblasts and connective tissue. The findings implicate the role of PDGFR?-dependent ECM and HGF production in fibroblasts that promotes the remodeling of connective tissue and suggest that PDGFR? may be a relevant target to regulate connective tissue remodeling. Twit Text FOAVip PDGFR plays a crucial role in connective tissue remodeling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26639755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26639755 #FOAvip English Wikipedia <ref>{{Cite pmid|26639755}}</ref> PDGFR? plays a crucial role in connective tissue remodeling #MMPMID26639755 Horikawa S; Ishii Y; Hamashima T; Yamamoto S; Mori H; Fujimori T; Shen J; Inoue R; Nishizono H; Itoh H; Majima M; Abraham D; Miyawaki T; Sasahara M Sci Rep 2015[]; 5 (ä): ä PMID26639755show ga Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-? (PDGFR?) in this process. In the present study, the Pdgfra gene was systemically inactivated in adult mouse (?-KO mouse), and the role of PDGFR? was examined in the subcutaneously implanted sponge matrices. PDGFR? expressed in the fibroblasts of Pdgfra-preserving control mice (Flox mice), was significantly reduced in the sponges in ?-KO mice. Neovascularized areas were largely suppressed in the ?-KO mice than in the Flox mice, whereas the other parameters related to the blood vessels and endothelial cells were similar. The deposition of collagen and fibronectin and the expression of collagen 1a1 and 3a1 genes were significantly reduced in ?-KO mice. There was a significantly decrease in the number and dividing fibroblasts in the ?-KO mice, and those of macrophages were similar between the two genotypes. Hepatocyte growth factor (Hgf) gene expression was suppressed in Pdgfra-inactivated fibroblasts and connective tissue. The findings implicate the role of PDGFR?-dependent ECM and HGF production in fibroblasts that promotes the remodeling of connective tissue and suggest that PDGFR? may be a relevant target to regulate connective tissue remodeling. äPDGFR? plays a crucial role in connective tissue remodeling (epmc).pdf DeepDyve Pubget Overpricing