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10.1038/jcbfm.2015.151 http://scihub22266oqcxt.onion/10.1038/jcbfm.2015.151 C4671114!4671114!26104291     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cereb+Blood+Flow+Metab 2015 ; 35 (12): 1950-6 Nephropedia Template TP {{tp|p=26104291|t=2015. The functional and structural changes in the basilar artery due to overpressure blast injury |pdf=|usr=}}{{26104291}} gab.com Text The functional and structural changes in the basilar artery due to overpressure blast injury JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26104291 #FOAvip Overpressure blast-wave induced brain injury (OBI) leads to progressive pathophysiologic changes resulting in a reduction in brain blood flow, blood brain barrier breakdown, edema, and cerebral ischemia. The aim of this study was to evaluate cerebral vascular function after single and repeated OBI. Male Sprague-Dawley rats were divided into three groups: Control (Naive), single OBI (30?psi peak pressure, 1 to 2?msec duration), and repeated (days 1, 4, and 7) OBI (r-OBI). Rats were killed 24?hours after injury and the basilar artery was isolated, cannulated, and pressurized (90?cm H2O). Vascular responses to potassium chloride (KCl) (30 to 100?mmol/L), endothelin-1 (10?12 to 10?7 mol/L), acetylcholine (ACh) (10?10 to 10?4 mol/L) and diethylamine-NONO-ate (DEA-NONO-ate) (10?10 to 10?4 mol/L) were evaluated. The OBI resulted in an increase in the contractile responses to endothelin and a decrease in the relaxant responses to ACh in both single and r-OBI groups. However, impaired DEA-NONO-ate-induced vasodilation and increased wall thickness to lumen ratio were observed only in the r-OBI group. The endothelin-1 type A (ETA) receptor and endothelial nitric oxide synthase (eNOS) immunoreactivity were significantly enhanced by OBI. These findings indicate that both single and r-OBI impairs cerebral vascular endothelium-dependent dilation, potentially a consequence of endothelial dysfunction and/or vascular remodelling in basilar arteries after OBI. Twit Text FOAVip The functional and structural changes in the basilar artery due to overpressure blast injury ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26104291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26104291 #FOAvip English Wikipedia <ref>{{Cite pmid|26104291}}</ref> The functional and structural changes in the basilar artery due to overpressure blast injury #MMPMID26104291 Toklu HZ; Muller-Delp J; Yang Z; Oktay ?; Sakarya Y; Strang K; Ghosh P; Delp MD; Scarpace PJ; Wang KK; Tümer N J Cereb Blood Flow Metab 2015[Dec]; 35 (12): 1950-6 PMID26104291show ga Overpressure blast-wave induced brain injury (OBI) leads to progressive pathophysiologic changes resulting in a reduction in brain blood flow, blood brain barrier breakdown, edema, and cerebral ischemia. The aim of this study was to evaluate cerebral vascular function after single and repeated OBI. Male Sprague-Dawley rats were divided into three groups: Control (Naive), single OBI (30?psi peak pressure, 1 to 2?msec duration), and repeated (days 1, 4, and 7) OBI (r-OBI). Rats were killed 24?hours after injury and the basilar artery was isolated, cannulated, and pressurized (90?cm H2O). Vascular responses to potassium chloride (KCl) (30 to 100?mmol/L), endothelin-1 (10?12 to 10?7 mol/L), acetylcholine (ACh) (10?10 to 10?4 mol/L) and diethylamine-NONO-ate (DEA-NONO-ate) (10?10 to 10?4 mol/L) were evaluated. The OBI resulted in an increase in the contractile responses to endothelin and a decrease in the relaxant responses to ACh in both single and r-OBI groups. However, impaired DEA-NONO-ate-induced vasodilation and increased wall thickness to lumen ratio were observed only in the r-OBI group. The endothelin-1 type A (ETA) receptor and endothelial nitric oxide synthase (eNOS) immunoreactivity were significantly enhanced by OBI. These findings indicate that both single and r-OBI impairs cerebral vascular endothelium-dependent dilation, potentially a consequence of endothelial dysfunction and/or vascular remodelling in basilar arteries after OBI. äThe functional and structural changes in the basilar artery due to ove(epmc).pdf DeepDyve Pubget Overpricing