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2015 ; 5
(ä): 17809
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gab.com Text
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English Wikipedia
Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released
from Human Neutrophils
#MMPMID26639836
Zhang Z
; Huang T
; Yu F
; Liu X
; Zhao C
; Chen X
; Kelvin DJ
; Gu J
Sci Rep
2015[Dec]; 5
(ä): 17809
PMID26639836
show ga
Various reports have indicated that a number of viruses could infect neutrophils,
but the multiplication of viruses in neutrophils was abortive. Based on our
previous finding that avian influenza viral RNA and proteins were present in the
nucleus of infected human neutrophils in vivo, we investigated the possibility of
2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible
release of infectious progeny from host cells. In this study we found that human
neutrophils in vitro without detectable level of sialic acid expression could be
infected by this virus strain. We also show that the infected neutrophils can not
only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce
infectious progeny. These findings suggest that infectious progeny of 2009 A
(H1N1) influenza virus could be replicated in and released from human neutrophils
with possible clinical implications.
|Adult
[MESH]
|Animals
[MESH]
|Cell Separation
[MESH]
|Chick Embryo
[MESH]
|Coculture Techniques
[MESH]
|Humans
[MESH]
|Influenza A Virus, H1N1 Subtype/genetics/*physiology
[MESH]