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2015 ; 21
(45
): 12882-7
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Comparison of Stretta procedure and toupet fundoplication for gastroesophageal
reflux disease-related extra-esophageal symptoms
#MMPMID26668513
Yan C
; Liang WT
; Wang ZG
; Hu ZW
; Wu JM
; Zhang C
; Chen MP
World J Gastroenterol
2015[Dec]; 21
(45
): 12882-7
PMID26668513
show ga
AIM: To compare the outcomes between the Stretta procedure and laparoscopic
toupet fundoplication (LTF) in patients with gastroesophageal reflux disease
(GERD)-related extra-esophageal symptoms. METHODS: From January 2011 to February
2012, a total of 98 patients diagnosed with GERD-related extra-esophageal
symptoms who met the inclusion criteria were enrolled in this study. All patients
who either underwent the Stretta procedure or LTF treatment have now completed
the 3-year follow-up. Primary outcome measures, including frequency and severity
of extra-esophageal symptoms, proton pump inhibitor (PPI) use, satisfaction, and
postoperative complications, were assessed. The results of the Stretta procedure
and LTF therapy were analyzed and compared. RESULTS: There were 47 patients in
the Stretta group and 51 patients in the LTF group. Ninety patients were
available at the 3-year follow-up. The total of the frequency and severity scores
for every symptom improved in both groups (P < 0.05). Improvement in symptom
scores of cough, sputum, and wheezing did not achieve statistical significance
between the two groups (P > 0.05). However, the score for globus hysterics was
different between the Stretta group and the LTF group (4.9 ± 2.24 vs 3.2 ± 2.63,
P < 0.05). After the Stretta procedure and LTF treatment, 29 and 33 patients in
each group achieved PPI therapy independence (61.7% vs 64.7%, P = 0.835). The
patients in the LTF group were more satisfied with their quality of life than
those in the Stretta procedure group (P < 0.05). Most complications resolved
without intervention within two weeks; however, two patients in the LTF group
still suffered from severe dysphagia 2 wk after the operation, and it improved
after bougie dilation treatment in both patients. CONCLUSION: The Stretta
procedure and LTF were both safe and effective for the control of GERD-related
extra-esophageal symptoms and the reduction of PPI use.