Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26583325
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Death+Dis
2015 ; 6
(11
): e1984
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Smad4 represses the generation of memory-precursor effector T cells but is
required for the differentiation of central memory T cells
#MMPMID26583325
Cao J
; Zhang X
; Wang Q
; Qiu G
; Hou C
; Wang J
; Cheng Q
; Lan Y
; Han H
; Shen H
; Zhang Y
; Yang X
; Shen B
; Zhang J
Cell Death Dis
2015[Nov]; 6
(11
): e1984
PMID26583325
show ga
The transcriptional regulation underlying the differentiation of CD8(+) effector
and memory T cells remains elusive. Here, we show that 18-month-old mice lacking
the transcription factor Smad4 (homolog 4 of mothers against decapentaplegic,
Drosophila), a key intracellular signaling effector for the TGF-? superfamily, in
T cells exhibited lower percentages of CD44(hi)CD8(+) T cells. To explore the
role of Smad4 in the activation/memory of CD8(+) T cells, 6- to 8-week-old mice
with or without Smad4 in T cells were challenged with Listeria monocytogenes.
Smad4 deficiency did not affect antigen-specific CD8(+) T-cell expansion but led
to partially impaired cytotoxic function. Less short-lived effector T cells but
more memory-precursor effector T cells were generated in the absence of Smad4.
Despite that, Smad4 deficiency led to reduced memory CD8(+) T-cell responses.
Further exploration revealed that the generation of central memory T cells was
impaired in the absence of Smad4 and the cells showed survival issue. In
mechanism, Smad4 deficiency led to aberrant transcriptional programs in
antigen-specific CD8(+) T cells. These findings demonstrated an essential role of
Smad4 in the control of effector and memory CD8(+) T-cell responses to infection.