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2015 ; 2015
(ä): 283021
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New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in
Acute Myocardial Infarction: Cross-Sectional Study
#MMPMID26682070
Alkuraishy HM
; Al-Gareeb AI
Emerg Med Int
2015[]; 2015
(ä): 283021
PMID26682070
show ga
Background. Serum omentin-1 level was low in the most types of ischemic heart
disease compared to normal subjects; it also dependently correlated with coronary
heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD.
Objective. The aim of the present study was to establish the links between
omentin-1 and acute myocardial infarction in metformin patients. Subjects and
Methods. A cross-sectional study was performed on eighty-five patients with type
II DM and acute MI. They are divided as follows: Group I, 62 patients with type
II DM who received metformin prior to onset of acute MI; Group II, 23 patients
with type II DM who did not receive metformin prior to onset of acute MI; and
Group III, 30 normal healthy controls. Venous blood was drawn from each
participant for determination of lipid profile, plasma omentin-1, cardiac
troponin-I (cTn-I) and other routine tests. Results. Patients that presented with
acute MI that received metformin show a significant difference in all biochemical
parameters (p < 0.001); metformin increases serum omentin-1 level and decreases
serum cardiac troponin-I level compared with control subjects and nonmetformin
treated patients. Conclusion. Metformin pharmacotherapy increases omentin-1 serum
levels and may be regarded as a potential agent in the prevention of the
occurrences of acute MI in diabetic patients.