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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Stem+Cells+Int 2016 ; 2016 (ä): ä Nephropedia Template TP
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Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin #MMPMID26681957
Reichert M; Blume K; Kleger A; Hartmann D; von Figura G
Stem Cells Int 2016[]; 2016 (ä): ä PMID26681957show ga
Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.