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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Endocrinol 2015 ; 2015 (ä): ä Nephropedia Template TP
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Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease #MMPMID26681940
Yong KL; Chng CL; Htoon HM; Lim LH; Seah LL
Int J Endocrinol 2015[]; 2015 (ä): ä PMID26681940show ga
Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All subjects had vital signs charted during and after infusions. Results. This study included 38 subjects and a total of 242 infusions administered. IVMP resulted in a small but significant percentage drop in mean SBP at 30?min (p < 0.001) and 60?min (p = 0.03) but no difference at 90?min. There was also small but significant percentage drop in mean DBP and HR (DBP: p < 0.001 for 30?min, p = 0.001 for 60?min, and p = 0.02 for 90?min and HR: p < 0.001 for 30?min, 60?min, and 90?min). There were no cumulative effects on change of blood pressure or HR. There were 6 episodes of bradycardia (2.5%) and 12 episodes of moderate to severe hypertension (5%). No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. IVMP demonstrated mild and noncumulative effects on vital signs. Severe hypertension may occur in susceptible individuals such as those with underlying hypertension and uncontrolled thyroid dysfunction, whereas bradycardia may be more likely in those on beta-blockers.