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10.1111/apt.12499 http://scihub22266oqcxt.onion/10.1111/apt.12499 C4670480!4670480 !24134498     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24134498 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adalimumab maintains remission of Crohn s disease after up to 4 years of treatment: data from CHARM and ADHERE |pdf=|usr=}}{{24134498 }} gab.com Text Adalimumab maintains remission of Crohn s disease after up to 4 years of treatment: data from CHARM and ADHERE JO: Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24134498 #FOAvip BACKGROUND: Therapies that maintain remission for patients with Crohn's disease are essential. Stable remission rates have been demonstrated for up to 2 years in adalimumab-treated patients with moderately to severely active Crohn's disease enrolled in the CHARM and ADHERE clinical trials. AIM: To present the long-term efficacy and safety of adalimumab therapy through 4 years of treatment. METHODS: Remission (CDAI <150), response (CR-100) and corticosteroid-free remission over 4 years, and maintenance of these endpoints beyond 1 year were assessed in CHARM early responders randomised to adalimumab. Corticosteroid-free remission was also assessed in all adalimumab-randomised patients using corticosteroids at baseline. Fistula healing was assessed in adalimumab-randomised patients with fistula at baseline. As observed, last observation carried forward and a hybrid nonresponder imputation analysis for year 4 (hNRI) were used to report efficacy. Adverse events were reported for any patient receiving at least one dose of adalimumab. RESULTS: Of 329 early responders randomised to adalimumab induction therapy, at least 30% achieved remission (99/329) or CR-100 (116/329) at year 4 of treatment (hNRI). The majority of patients (54%) with remission at year 1 maintained this endpoint at year 4 (hNRI). At year 4, 16% of patients taking corticosteroids at baseline were in corticosteroid-free remission and 24% of patients with fistulae at baseline had healed fistulae. The incidence rates of adverse events remained stable over time. CONCLUSIONS: Prolonged adalimumab therapy maintained clinical remission and response in patients with moderately to severely active Crohn's disease for up to 4 years. No increased risk of adverse events or new safety signals were identified with long-term maintenance therapy. (clinicaltrials.gov number: NCT00077779). Twit Text FOAVip Adalimumab maintains remission of Crohn s disease after up to 4 years of treatment: data from CHARM and ADHERE ????Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24134498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24134498 #FOAvip English Wikipedia <ref>{{Cite pmid|24134498 }}</ref> Adalimumab maintains remission of Crohn s disease after up to 4 years of treatment: data from CHARM and ADHERE #MMPMID24134498 Panaccione R ; Colombel JF ; Sandborn WJ ; D'Haens G ; Zhou Q ; Pollack PF ; Thakkar RB ; Robinson AM Aliment Pharmacol Ther 2013[Nov]; 38 (10 ): 1236-47 PMID24134498 show ga BACKGROUND: Therapies that maintain remission for patients with Crohn's disease are essential. Stable remission rates have been demonstrated for up to 2 years in adalimumab-treated patients with moderately to severely active Crohn's disease enrolled in the CHARM and ADHERE clinical trials. AIM: To present the long-term efficacy and safety of adalimumab therapy through 4 years of treatment. METHODS: Remission (CDAI <150), response (CR-100) and corticosteroid-free remission over 4 years, and maintenance of these endpoints beyond 1 year were assessed in CHARM early responders randomised to adalimumab. Corticosteroid-free remission was also assessed in all adalimumab-randomised patients using corticosteroids at baseline. Fistula healing was assessed in adalimumab-randomised patients with fistula at baseline. As observed, last observation carried forward and a hybrid nonresponder imputation analysis for year 4 (hNRI) were used to report efficacy. Adverse events were reported for any patient receiving at least one dose of adalimumab. RESULTS: Of 329 early responders randomised to adalimumab induction therapy, at least 30% achieved remission (99/329) or CR-100 (116/329) at year 4 of treatment (hNRI). The majority of patients (54%) with remission at year 1 maintained this endpoint at year 4 (hNRI). At year 4, 16% of patients taking corticosteroids at baseline were in corticosteroid-free remission and 24% of patients with fistulae at baseline had healed fistulae. The incidence rates of adverse events remained stable over time. CONCLUSIONS: Prolonged adalimumab therapy maintained clinical remission and response in patients with moderately to severely active Crohn's disease for up to 4 years. No increased risk of adverse events or new safety signals were identified with long-term maintenance therapy. (clinicaltrials.gov number: NCT00077779). |Adalimumab [MESH] |Anti-Inflammatory Agents/administration & dosage/adverse effects/*therapeutic use [MESH] |Antibodies, Monoclonal, Humanized/administration & dosage/adverse effects/*therapeutic use [MESH] |Crohn Disease/*drug therapy/physiopathology [MESH] |Double-Blind Method [MESH] |Glucocorticoids/administration & dosage/therapeutic use [MESH] |Humans [MESH] |Remission Induction [MESH] |Severity of Illness Index [MESH] |Time Factors [MESH]Adalimumab maintains remission of Crohn s disease after up to 4 years (epmc).pdf DeepDyve Pubget Overpricing