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10.2147/DDDT.S93964 http://scihub22266oqcxt.onion/10.2147/DDDT.S93964 C4670018!4670018 !26664048     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26664048 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2015 ; 9 (ä): 6269-74 Nephropedia Template TP {{tp|p=26664048 |t=2015. Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-?1/Smad7 signaling |pdf=|usr=}}{{26664048 }} gab.com Text Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF- 1/Smad7 signaling JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26664048 #FOAvip BACKGROUND: Diabetic nephropathy (DN) is a major cause of chronic kidney failure and characterized by excessive deposition of extracellular matrix. Evidence have shown that transforming growth factor-?1 (TGF-?1) is a key mediator in the development of DN. However, treatment of DN by blocking the TGF-?1/Smad7 pathway remains limited. Xiaokeping mixture (XKP), a traditional Chinese herbal compound, has been used for treatment in patients with DN for many years. METHODS: In the present study, TGF-?1/Smad7 pathway analysis was used to evaluate the therapeutic effect of XKP on DN rats induced by streptozotocin and to address the underlying molecular mechanism. Male rats were divided into four groups: normal control, untreated control group (fed with high fat), irbesartan-treated DN, and XKP-treated DN, respectively. Levels of serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol were detected. Pathological changes of renal tissues were observed by hematoxylin-eosin staining. Immunohistochemical and Western blot analysis were used to detect the expressions of TGF-?1 and Smad7. RESULTS: The results demonstrated that XKP can effectively reduce the levels of glucose, serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol. Further studies indicated that inhibition of DN in XKP-treated DN rats was associated with inhibition of TGF-?1/Smad7 signaling as demonstrated by downregulation of TGF-?1 but upregulation of Smad7. CONCLUSION: The data obtained from the present study indicate that XKP may be a therapeutic agent for DN. Twit Text FOAVip Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF- 1/Smad7 signaling ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26664048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26664048 #FOAvip English Wikipedia <ref>{{Cite pmid|26664048 }}</ref> Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-?1/Smad7 signaling #MMPMID26664048 Xin C ; Xia Z ; Jiang C ; Lin M ; Li G Drug Des Devel Ther 2015[]; 9 (ä): 6269-74 PMID26664048 show ga BACKGROUND: Diabetic nephropathy (DN) is a major cause of chronic kidney failure and characterized by excessive deposition of extracellular matrix. Evidence have shown that transforming growth factor-?1 (TGF-?1) is a key mediator in the development of DN. However, treatment of DN by blocking the TGF-?1/Smad7 pathway remains limited. Xiaokeping mixture (XKP), a traditional Chinese herbal compound, has been used for treatment in patients with DN for many years. METHODS: In the present study, TGF-?1/Smad7 pathway analysis was used to evaluate the therapeutic effect of XKP on DN rats induced by streptozotocin and to address the underlying molecular mechanism. Male rats were divided into four groups: normal control, untreated control group (fed with high fat), irbesartan-treated DN, and XKP-treated DN, respectively. Levels of serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol were detected. Pathological changes of renal tissues were observed by hematoxylin-eosin staining. Immunohistochemical and Western blot analysis were used to detect the expressions of TGF-?1 and Smad7. RESULTS: The results demonstrated that XKP can effectively reduce the levels of glucose, serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol. Further studies indicated that inhibition of DN in XKP-treated DN rats was associated with inhibition of TGF-?1/Smad7 signaling as demonstrated by downregulation of TGF-?1 but upregulation of Smad7. CONCLUSION: The data obtained from the present study indicate that XKP may be a therapeutic agent for DN. |Administration, Oral [MESH] |Animals [MESH] |Diabetes Mellitus, Experimental/chemically induced/*drug therapy/metabolism [MESH] |Diabetic Nephropathies/chemically induced/*drug therapy/metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |Drugs, Chinese Herbal/administration & dosage/*therapeutic use [MESH] |Male [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/*drug effects [MESH] |Smad7 Protein/*antagonists & inhibitors/metabolism [MESH] |Streptozocin [MESH] |Structure-Activity Relationship [MESH]Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-ind(epmc).pdf DeepDyve Pubget Overpricing