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2015 ; 14
(ä): 916-25
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The erratic antibiotic susceptibility patterns of bacterial pathogens causing
urinary tract infections
#MMPMID26648826
Ahmed I
; Sajed M
; Sultan A
; Murtaza I
; Yousaf S
; Maqsood B
; Vanhara P
; Anees M
EXCLI J
2015[]; 14
(ä): 916-25
PMID26648826
show ga
Increasing trend of antibiotic resistance and expression of Extended Spectrum
Beta Lactamases (ESBLs) are serious threats for public health as they render the
treatment ineffective. Present study was designed to elucidate the
antibiotic-susceptibility patterns of ESBL and non-ESBL producing E. coli and K.
pneumoniae causing urinary tract infections so that the ineffective antibiotics
could be removed from the line of treatment. The bacterial isolates obtained from
the urine of patients visiting a tertiary health care facility were cultured for
strain identification using API20E. Antimicrobial susceptibility and ESBL
detection were done by Kirby-bauer diffusion technique. Almost 53.4 % isolates of
E. coli and 24.5 % isolates of K. pneumoniae were found to be ESBL producers. The
ESBL producing bacteria were found to be more resistant towards various
antibiotics. The most effective drugs against E. coli ESBL isolates were imipenem
(99.54 %), ampicillin-sulbactam (97.48 %), piperacillin-tazobactam (96.86 %),
fosfomycin (94.51 %), amikacin (92.26 %) and nitrofurantoin (90.68 %). The most
effective drugs against K. pneumoniae ESBL isolates were imipenem (97.62 %),
piperacillin-tazobactam (95.35 %), ampicillin-sulbactam (90.48 %) and amikacin
(88.37 %). The antibiotics having the highest resistance, particularly by the
ESBL producers were amoxicillin clavulanic acid, sulphamethoxalzole/
trimethoprim, cefuroxime, cefpirome, ceftriaxone and ciprofloxacin. Most of the
isolates showed multi drug resistance (MDR). High frequency of ESBL producing E.
coli and K. pneumoniae were observed as compared to previous data. Penicillins,
cephalosporins and some representatives of fluoroquinolones were least effective
against the common UTIs and are recommended to be removed from the line of
treatment.
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