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10.1038/cddis.2015.162 http://scihub22266oqcxt.onion/10.1038/cddis.2015.162 C4669840!4669840!26086965     free     free     free       Cell+Death+Dis 2015 ; 6 (6): e1792- Nephropedia Template TP {{tp|p=26086965|t=2015. T-cell exhaustion in the tumor microenvironment |pdf=|usr=}}{{26086965}} gab.com Text T-cell exhaustion in the tumor microenvironment JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26086965 #FOAvip T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials. Twit Text FOAVip T-cell exhaustion in the tumor microenvironment ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26086965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26086965 #FOAvip English Wikipedia <ref>{{Cite pmid|26086965}}</ref> T-cell exhaustion in the tumor microenvironment #MMPMID26086965 Jiang Y; Li Y; Zhu B Cell Death Dis 2015[Jun]; 6 (6): e1792- PMID26086965show ga T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials. äT-cell exhaustion in the tumor microenvironment (epmc).pdf DeepDyve Pubget Overpricing