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10.1038/cddis.2014.579 http://scihub22266oqcxt.onion/10.1038/cddis.2014.579 C4669775!4669775 !25611388     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25611388 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion |pdf=|usr=}}{{25611388 }} gab.com Text Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25611388 #FOAvip Obesity leads to adipose tissue inflammation that is characterized by increased release of proinflammatory molecules and the recruitment of activated immune cells. Although macrophages are present in the highest number among the immune cells in obese adipose tissue, not much is known about their direct interaction with adipocytes. We have introduced an ex vivo experimental system to characterize the cellular interactions and the profile of secreted cytokines in cocultures of macrophages and human adipocytes differentiated from either mesenchymal stem cells or a preadipocyte cell line. As observed by time-lapse microscopy, flow, and laser-scanning cytometry, macrophages phagocytosed bites of adipocytes (trogocytosis), which led to their de novo, phagocytosis and NF-?B-dependent synthesis, then release of interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1. IL-6 secretion was not accompanied by secretion of other proinflammatory cytokines, such as tumor necrosis factor (TNF)-? and IL-8, except MCP-1. LPS-induced release of TNF-?, IL-8 and MCP-1 was decreased in the presence of the differentiated adipocytes but the IL-6 level did not subside suggesting that phagocytosis-dependent IL-6 secretion may have significant regulatory function in the inflamed adipose tissue. Twit Text FOAVip Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25611388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25611388 #FOAvip English Wikipedia <ref>{{Cite pmid|25611388 }}</ref> Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion #MMPMID25611388 Sárvári AK ; Doan-Xuan QM ; Bacsó Z ; Csomós I ; Balajthy Z ; Fésüs L Cell Death Dis 2015[Jan]; 6 (1 ): e1613 PMID25611388 show ga Obesity leads to adipose tissue inflammation that is characterized by increased release of proinflammatory molecules and the recruitment of activated immune cells. Although macrophages are present in the highest number among the immune cells in obese adipose tissue, not much is known about their direct interaction with adipocytes. We have introduced an ex vivo experimental system to characterize the cellular interactions and the profile of secreted cytokines in cocultures of macrophages and human adipocytes differentiated from either mesenchymal stem cells or a preadipocyte cell line. As observed by time-lapse microscopy, flow, and laser-scanning cytometry, macrophages phagocytosed bites of adipocytes (trogocytosis), which led to their de novo, phagocytosis and NF-?B-dependent synthesis, then release of interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1. IL-6 secretion was not accompanied by secretion of other proinflammatory cytokines, such as tumor necrosis factor (TNF)-? and IL-8, except MCP-1. LPS-induced release of TNF-?, IL-8 and MCP-1 was decreased in the presence of the differentiated adipocytes but the IL-6 level did not subside suggesting that phagocytosis-dependent IL-6 secretion may have significant regulatory function in the inflamed adipose tissue. |*Cell Communication/drug effects [MESH] |*Cell Differentiation/drug effects [MESH] |*Phagocytosis/drug effects [MESH] |Adipocytes/*cytology/drug effects/metabolism [MESH] |Brefeldin A/pharmacology [MESH] |Coculture Techniques [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Inflammation Mediators/metabolism [MESH] |Interleukin-6/*metabolism [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages/*cytology/drug effects/metabolism [MESH]Interaction of differentiated human adipocytes with macrophages leads (epmc).pdf DeepDyve Pubget Overpricing