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10.1038/cddis.2014.565 http://scihub22266oqcxt.onion/10.1038/cddis.2014.565 C4669763!4669763!25590810     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2015 ; 6 (1): e1600- Nephropedia Template TP {{tp|p=25590810|t=2015. The role of hypoxia-inducible factor-2 in digestive system cancers |pdf=|usr=}}{{25590810}} gab.com Text The role of hypoxia-inducible factor-2 in digestive system cancers JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25590810 #FOAvip Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1? and HIF-2?, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1? and HIF-2?, emerging evidence suggests differences between both molecules in terms of transcriptional targets as well as impact on multiple physiological pathways and tumorigenesis. To date, much progress has been made toward understanding the roles of HIF-2? in digestive system cancers. Indeed, HIF-2? has been shown to regulate multiple aspects of digestive system cancers, including cell proliferation, angiogenesis and apoptosis, metabolism, metastasis and resistance to chemotherapy. These findings make HIF-2? a critical regulator of this malignant phenotype. Here we summarize the function of HIF-2 during cancer development as well as its contribution to tumorigenesis in digestive system malignancies. Twit Text FOAVip The role of hypoxia-inducible factor-2 in digestive system cancers ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25590810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25590810 #FOAvip English Wikipedia <ref>{{Cite pmid|25590810}}</ref> The role of hypoxia-inducible factor-2 in digestive system cancers #MMPMID25590810 Zhao J; Du F; Shen G; Zheng F; Xu B Cell Death Dis 2015[Jan]; 6 (1): e1600- PMID25590810show ga Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1? and HIF-2?, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1? and HIF-2?, emerging evidence suggests differences between both molecules in terms of transcriptional targets as well as impact on multiple physiological pathways and tumorigenesis. To date, much progress has been made toward understanding the roles of HIF-2? in digestive system cancers. Indeed, HIF-2? has been shown to regulate multiple aspects of digestive system cancers, including cell proliferation, angiogenesis and apoptosis, metabolism, metastasis and resistance to chemotherapy. These findings make HIF-2? a critical regulator of this malignant phenotype. Here we summarize the function of HIF-2 during cancer development as well as its contribution to tumorigenesis in digestive system malignancies. äThe role of hypoxia-inducible factor-2 in digestive system cancers (epmc).pdf DeepDyve Pubget Overpricing