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10.1038/cddis.2015.122 http://scihub22266oqcxt.onion/10.1038/cddis.2015.122 C4669701!4669701 !25950488     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25950488 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2015 ; 6 (5 ): e1758 Nephropedia Template TP {{tp|p=25950488 |t=2015. IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity |pdf=|usr=}}{{25950488 }} gab.com Text IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25950488 #FOAvip RIG-I-like receptors are the key cytosolic sensors for RNA viruses and induce the production of type I interferons (IFN) and pro-inflammatory cytokines through a sole adaptor IFN-? promoter stimulator-1 (IPS-1) (also known as Cardif, MAVS and VISA) in antiviral innate immunity. These sensors also have a pivotal role in anticancer activity through induction of apoptosis. However, the mechanism for their anticancer activity is poorly understood. Here, we show that anticancer vaccine adjuvant, PolyIC (primarily sensed by MDA5) and the oncolytic virus, Newcastle disease virus (NDV) (sensed by RIG-I), induce anticancer activity. The ectopic expression of IPS-1 into type I IFN-responsive and non-responsive cancer cells induces anticancer activity. PolyIC transfection and NDV infection upregulate pro-apoptotic gene TRAIL and downregulate the anti-apoptotic genes BCL2, BIRC3 and PRKCE. Furthermore, stable knockdown of IPS-1, IRF3 or IRF7 in IFN-non-responsive cancer cells show reduced anticancer activity by suppressing apoptosis via TRAIL and anti-apoptotic genes. Collectively, our study shows that IPS-1 induces anticancer activity through upregulation of pro-apoptotic gene TRAIL and downregulation of the anti-apoptotic genes BCL2, BIRC3 and PRKCE via IRF3 and IRF7 in type I IFN-dependent and -independent manners. Twit Text FOAVip IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25950488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25950488 #FOAvip English Wikipedia <ref>{{Cite pmid|25950488 }}</ref> IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity #MMPMID25950488 Kumar S ; Ingle H ; Mishra S ; Mahla RS ; Kumar A ; Kawai T ; Akira S ; Takaoka A ; Raut AA ; Kumar H Cell Death Dis 2015[May]; 6 (5 ): e1758 PMID25950488 show ga RIG-I-like receptors are the key cytosolic sensors for RNA viruses and induce the production of type I interferons (IFN) and pro-inflammatory cytokines through a sole adaptor IFN-? promoter stimulator-1 (IPS-1) (also known as Cardif, MAVS and VISA) in antiviral innate immunity. These sensors also have a pivotal role in anticancer activity through induction of apoptosis. However, the mechanism for their anticancer activity is poorly understood. Here, we show that anticancer vaccine adjuvant, PolyIC (primarily sensed by MDA5) and the oncolytic virus, Newcastle disease virus (NDV) (sensed by RIG-I), induce anticancer activity. The ectopic expression of IPS-1 into type I IFN-responsive and non-responsive cancer cells induces anticancer activity. PolyIC transfection and NDV infection upregulate pro-apoptotic gene TRAIL and downregulate the anti-apoptotic genes BCL2, BIRC3 and PRKCE. Furthermore, stable knockdown of IPS-1, IRF3 or IRF7 in IFN-non-responsive cancer cells show reduced anticancer activity by suppressing apoptosis via TRAIL and anti-apoptotic genes. Collectively, our study shows that IPS-1 induces anticancer activity through upregulation of pro-apoptotic gene TRAIL and downregulation of the anti-apoptotic genes BCL2, BIRC3 and PRKCE via IRF3 and IRF7 in type I IFN-dependent and -independent manners. |Adaptor Proteins, Signal Transducing/*genetics [MESH] |Apoptosis/immunology [MESH] |Baculoviral IAP Repeat-Containing 3 Protein [MESH] |Cancer Vaccines/immunology [MESH] |Cell Line, Tumor [MESH] |Down-Regulation [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Inhibitor of Apoptosis Proteins/biosynthesis/genetics [MESH] |Interferon Regulatory Factor-3/genetics [MESH] |Interferon Regulatory Factor-7/genetics [MESH] |Interferon Type I/*immunology [MESH] |Neoplasm Invasiveness/pathology [MESH] |Neoplasms/*immunology [MESH] |Newcastle disease virus/*immunology [MESH] |Poly I-C/immunology [MESH] |Protein Kinase C-epsilon/biosynthesis/genetics [MESH] |Proto-Oncogene Proteins c-bcl-2/biosynthesis/genetics [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH] |Signal Transduction/immunology [MESH] |TNF-Related Apoptosis-Inducing Ligand/*biosynthesis/genetics [MESH] |Ubiquitin-Protein Ligases/biosynthesis/genetics [MESH]IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I (epmc).pdf DeepDyve Pubget Overpricing