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10.1186/s13075-015-0874-0 http://scihub22266oqcxt.onion/10.1186/s13075-015-0874-0 C4669672!4669672!26634344     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Res+Ther 2015 ; 17 (ä): ä Nephropedia Template TP {{tp|p=26634344|t=2015. Statistical considerations for stopping systemic lupus erythematosus clinical trials earlier |pdf=|usr=}}{{26634344}} gab.com Text Statistical considerations for stopping systemic lupus erythematosus clinical trials earlier JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26634344 #FOAvip Group sequential designs are used to potentially shorten randomized clinical trials and thereby reduce subject burden, improve safety, and save time and resources. Clinical trials comparing treatments for systemic lupus erythematosus (SLE) might adopt such designs if the ordinal outcome scales for SLE, such as the Systemic Lupus Activity Measure and Systemic Lupus Erythematosus Disease Activity Index, were more like continuous outcome scales with interval properties. After describing the basic features of sequential trials and highlighting some major issues in their design, we propose approaches that mitigate these issues. In particular, high-speed computing has accelerated advances in sequential design, making available a variety of designs that can be implemented with minimal technical support. The challenge now is to understand the concepts behind such flexible designs and then to apply them to improve studies of SLE. Twit Text FOAVip Statistical considerations for stopping systemic lupus erythematosus clinical trials earlier ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26634344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26634344 #FOAvip English Wikipedia <ref>{{Cite pmid|26634344}}</ref> Statistical considerations for stopping systemic lupus erythematosus clinical trials earlier #MMPMID26634344 Lew RA; Liang MH; Doros G Arthritis Res Ther 2015[]; 17 (ä): ä PMID26634344show ga Group sequential designs are used to potentially shorten randomized clinical trials and thereby reduce subject burden, improve safety, and save time and resources. Clinical trials comparing treatments for systemic lupus erythematosus (SLE) might adopt such designs if the ordinal outcome scales for SLE, such as the Systemic Lupus Activity Measure and Systemic Lupus Erythematosus Disease Activity Index, were more like continuous outcome scales with interval properties. After describing the basic features of sequential trials and highlighting some major issues in their design, we propose approaches that mitigate these issues. In particular, high-speed computing has accelerated advances in sequential design, making available a variety of designs that can be implemented with minimal technical support. The challenge now is to understand the concepts behind such flexible designs and then to apply them to improve studies of SLE. äStatistical considerations for stopping systemic lupus erythematosus c(epmc).pdf DeepDyve Pubget Overpricing