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2015 ; 16
(ä): 200
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gab.com Text
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Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the
treatment of idiopathic membranous nephropathy: a prospective cohort study
#MMPMID26637482
Liu S
; Li X
; Li H
; Liang Q
; Chen J
; Chen J
BMC Nephrol
2015[Dec]; 16
(ä): 200
PMID26637482
show ga
BACKGROUND: Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic
syndrome among adults. Considering the natural course of IMN, when to treat and
with which immunosuppressive treatment need to be carefully considered in such
patients. A combination of tripterygium wilfordii multiglycosides (TWG) and
prednisone may be an effective option for treating patients with IMN. METHODS: In
this prospective cohort study, we enrolled patients with biopsy-proven IMN at our
kidney centre. One cohort received TWG combined with prednisone, whereas another
cohort received tacrolimus (TAC) combined with prednisone, for 36 weeks. The
primary outcome was the remission rate, whereas the secondary outcomes included
the time to remission, relapse rate, changes in serum albumin levels and daily
urinary protein levels, estimated glomerular filtration rate, and adverse events.
RESULTS: A total of 53 patients with IMN met the criteria for enrollment, and all
patients completed the therapy. At the end of the 36-week therapy, remission
(either partial remission [PR] or complete remission [CR]) was observed in 20
patients (86.9 %) receiving TWG and in 27 patients (90.0 %) receiving TAC (p >
0.05), whereas CR was noted in 12 patients (52.2 %) receiving TWG and 14 patients
(46.7 %) receiving TAC (p > 0.05). The probability of remission was similar for
both the TWG and TAC groups (p > 0.05, by log-bank test). The mean time for
achieving remission was 11.8 ± 12.5 weeks in the TWG group and 8.5 ± 9.1 weeks in
the TAC group (p > 0.05). CONCLUSIONS: The combination of TWG and predisone is an
effective and safe therapy for IMN.
|Adult
[MESH]
|Cohort Studies
[MESH]
|Drugs, Chinese Herbal/*administration & dosage
[MESH]