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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Crit+Care 2015 ; 19 (ä): ä Nephropedia Template TP
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Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials #MMPMID26635016
Hosokawa K; Nishimura M; Egi M; Vincent JL
Crit Care 2015[]; 19 (ä): ä PMID26635016show ga
Introduction: The optimal timing of tracheotomy in critically ill patients remains a topic of debate. We performed a systematic review to clarify the potential benefits of early versus late tracheotomy. Methods: We searched PubMed and CENTRAL for randomized controlled trials that compared outcomes in patients managed with early and late tracheotomy. A random-effects meta-analysis, combining data from three a priori-defined categories of timing of tracheotomy (within 4 versus after 10 days, within 4 versus after 5 days, within 10 versus after 10 days), was performed to estimate the weighted mean difference (WMD) or odds ratio (OR). Results: Of the 142 studies identified in the search, 12, including a total of 2,689 patients, met the inclusion criteria. The tracheotomy rate was significantly higher with early than with late tracheotomy (87 % versus 53 %, OR 16.1 (5.7-45.7); p?<0.01). Early tracheotomy was associated with more ventilator-free days (WMD 2.12 (0.94, 3.30), p?<0.01), a shorter ICU stay (WMD -5.14 (-9.99, -0.28), p?=?0.04), a shorter duration of sedation (WMD -5.07 (-10.03, -0.10), p?<0.05) and reduced long-term mortality (OR 0.83 (0.69-0.99), p?=?0.04) than late tracheotomy. Conclusions: This updated meta-analysis reveals that early tracheotomy is associated with higher tracheotomy rates and better outcomes, including more ventilator-free days, shorter ICU stays, less sedation, and reduced long-term mortality, compared to late tracheotomy. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-015-1138-8) contains supplementary material, which is available to authorized users.