Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25351682
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Orig+Life+Evol+Biosph
2014 ; 44
(3
): 197-208
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Search for the most primitive membranes and their reinforcers: a review of the
polyprenyl phosphates theory
#MMPMID25351682
Nakatani Y
; Ribeiro N
; Streiff S
; Gotoh M
; Pozzi G
; Désaubry L
; Milon A
Orig Life Evol Biosph
2014[Sep]; 44
(3
): 197-208
PMID25351682
show ga
Terpenoids have an essential function in present-day cellular membranes, either
as membrane reinforcers in Eucarya and Bacteria or as principal membrane
constituents in Archaea. We have shown that some terpenoids, such as cholesterol
and ?, ?-dipolar carotenoids reinforce lipid membranes by measuring the water
permeability of unilamellar vesicles. It was possible to arrange the known
membrane terpenoids in a 'phylogenetic' sequence, and a retrograde analysis led
us to conceive that single-chain polyprenyl phosphates might have been
'primitive' membrane constituents. By using an optical microscopy, we have
observed that polyprenyl phosphates containing 15 to 30 C-atoms form giant
vesicles in water in a wide pH range. The addition of 10 % molar of some
polyprenols to polyprenyl phosphate vesicles have been shown to reduce the water
permeability of membranes even more efficiently than the equimolecular addition
of cholesterol. A 'prebiotic' synthesis of C10 and C15 prenols from C5
monoprenols was achieved in the presence of a montmorillonite clay. Hypothetical
pathway from C1 or C2 units to 'primitive' membranes and that from 'primitive'
membranes to archaeal lipids are presented.