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10.1007/s11084-014-9365-6

http://scihub22266oqcxt.onion/10.1007/s11084-014-9365-6
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suck abstract from ncbi


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pmid25351682
      Orig+Life+Evol+Biosph 2014 ; 44 (3 ): 197-208
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  • Search for the most primitive membranes and their reinforcers: a review of the polyprenyl phosphates theory #MMPMID25351682
  • Nakatani Y ; Ribeiro N ; Streiff S ; Gotoh M ; Pozzi G ; Désaubry L ; Milon A
  • Orig Life Evol Biosph 2014[Sep]; 44 (3 ): 197-208 PMID25351682 show ga
  • Terpenoids have an essential function in present-day cellular membranes, either as membrane reinforcers in Eucarya and Bacteria or as principal membrane constituents in Archaea. We have shown that some terpenoids, such as cholesterol and ?, ?-dipolar carotenoids reinforce lipid membranes by measuring the water permeability of unilamellar vesicles. It was possible to arrange the known membrane terpenoids in a 'phylogenetic' sequence, and a retrograde analysis led us to conceive that single-chain polyprenyl phosphates might have been 'primitive' membrane constituents. By using an optical microscopy, we have observed that polyprenyl phosphates containing 15 to 30 C-atoms form giant vesicles in water in a wide pH range. The addition of 10 % molar of some polyprenols to polyprenyl phosphate vesicles have been shown to reduce the water permeability of membranes even more efficiently than the equimolecular addition of cholesterol. A 'prebiotic' synthesis of C10 and C15 prenols from C5 monoprenols was achieved in the presence of a montmorillonite clay. Hypothetical pathway from C1 or C2 units to 'primitive' membranes and that from 'primitive' membranes to archaeal lipids are presented.
  • |*Evolution, Molecular [MESH]
  • |Aluminum Silicates [MESH]
  • |Archaea/*chemistry [MESH]
  • |Bacteria/chemistry [MESH]
  • |Bentonite [MESH]
  • |Carotenoids/chemistry [MESH]
  • |Cell Membrane Permeability [MESH]
  • |Cell Membrane/*chemistry [MESH]
  • |Cholesterol/chemistry [MESH]
  • |Clay [MESH]
  • |Eukaryota/chemistry [MESH]
  • |Hydrogen-Ion Concentration [MESH]
  • |Origin of Life [MESH]
  • |Polyisoprenyl Phosphates/*chemistry [MESH]
  • |Terpenes/chemistry [MESH]
  • |Unilamellar Liposomes/chemistry [MESH]


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