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10.1038/srep17476 http://scihub22266oqcxt.onion/10.1038/srep17476 C4669453!4669453 !26635083     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26635083 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 17476 Nephropedia Template TP {{tp|p=26635083 |t=2015. Effects of histamine H1 receptor signaling on glucocorticoid receptor activity Role of canonical and non-canonical pathways |pdf=|usr=}}{{26635083 }} gab.com Text Effects of histamine H1 receptor signaling on glucocorticoid receptor activity Role of canonical and non-canonical pathways JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26635083 #FOAvip Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma. Consistent with the high morbidity levels of such inflammatory conditions, these receptors are the targets of a vast number of approved drugs, and in many situations their ligands are co-administered. However, this drug association has no clear rationale and has arisen from clinical practice. We hypothesized that H1R signaling could affect GR-mediated activity, impacting on its transcriptional outcome. Indeed, our results show a dual regulation of GR activity by the H1R: a potentiation mediated by G-protein ?? subunits and a parallel inhibitory effect mediated by G?q-PLC pathway. Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the G?q-PLC pathway by H1R inverse agonists resulted also in a potentiation of GR activity. Moreover, histamine and clinically relevant antihistamines synergized with the GR agonist dexamethasone to induce gene transactivation and transrepression in a gene-specific manner. Our work provides a delineation of molecular mechanisms underlying the widespread clinical association of antihistamines and GR agonists, which may contribute to future dosage optimization and reduction of well-described side effects associated with glucocorticoid administration. Twit Text FOAVip Effects of histamine H1 receptor signaling on glucocorticoid receptor activity Role of canonical and non-canonical pathways ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26635083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26635083 #FOAvip English Wikipedia <ref>{{Cite pmid|26635083 }}</ref> Effects of histamine H1 receptor signaling on glucocorticoid receptor activity Role of canonical and non-canonical pathways #MMPMID26635083 Zappia CD ; Granja-Galeano G ; Fernández N ; Shayo C ; Davio C ; Fitzsimons CP ; Monczor F Sci Rep 2015[Dec]; 5 (ä): 17476 PMID26635083 show ga Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma. Consistent with the high morbidity levels of such inflammatory conditions, these receptors are the targets of a vast number of approved drugs, and in many situations their ligands are co-administered. However, this drug association has no clear rationale and has arisen from clinical practice. We hypothesized that H1R signaling could affect GR-mediated activity, impacting on its transcriptional outcome. Indeed, our results show a dual regulation of GR activity by the H1R: a potentiation mediated by G-protein ?? subunits and a parallel inhibitory effect mediated by G?q-PLC pathway. Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the G?q-PLC pathway by H1R inverse agonists resulted also in a potentiation of GR activity. Moreover, histamine and clinically relevant antihistamines synergized with the GR agonist dexamethasone to induce gene transactivation and transrepression in a gene-specific manner. Our work provides a delineation of molecular mechanisms underlying the widespread clinical association of antihistamines and GR agonists, which may contribute to future dosage optimization and reduction of well-described side effects associated with glucocorticoid administration. |Asthma/*drug therapy/metabolism/pathology [MESH] |Corticosterone/administration & dosage [MESH] |Dermatitis, Atopic/*drug therapy/metabolism/pathology [MESH] |Dexamethasone/administration & dosage [MESH] |HeLa Cells [MESH] |Histamine Agonists/administration & dosage/metabolism [MESH] |Histamine H1 Antagonists/metabolism [MESH] |Histamine/metabolism [MESH] |Humans [MESH] |Receptors, Glucocorticoid/genetics/*metabolism [MESH] |Receptors, Histamine H1/genetics/*metabolism [MESH] |Signal Transduction [MESH]Effects of histamine H1 receptor signaling on glucocorticoid receptor (epmc).pdf DeepDyve Pubget Overpricing