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10.1016/j.jmb.2015.02.016 http://scihub22266oqcxt.onion/10.1016/j.jmb.2015.02.016 C4669196!4669196!25728651     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2015 ; 427 (11): 1995-2012 Nephropedia Template TP {{tp|p=25728651|t=2015. A Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms |pdf=|usr=}}{{25728651}} gab.com Text A Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25728651 #FOAvip The sensing of viral DNA is an essential step of cellular immune response to infections with DNA viruses. These human pathogens are spread worldwide, triggering a wide range of virus-induced diseases, and are associated with high levels of morbidity and mortality. Despite similarities between DNA molecules, mammalian cells have the remarkable ability to distinguish viral DNA from their own DNA. This detection is carried out by specialized antiviral proteins, called DNA sensors. These sensors bind to foreign DNA to activate downstream immune signaling pathways and alert neighboring cells by eliciting the expression of antiviral cytokines. The sensing of viral DNA was shown to occur both in the cytoplasm and nucleus of infected cells, disproving the notion that sensing occurred by simple spatial separation of viral and host DNA. A number of omic approaches, in particular mass spectrometry-based proteomic methods, have significantly contributed to the constantly evolving field of viral DNA sensing. Here, we review the impact of omic methods on the identification of viral DNA sensors, as well as on the characterization of mechanisms involved in host defense or viral immune evasion. Twit Text FOAVip A Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25728651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25728651 #FOAvip English Wikipedia <ref>{{Cite pmid|25728651}}</ref> A Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms #MMPMID25728651 Crow MS; Javitt A; Cristea IM J Mol Biol 2015[Jun]; 427 (11): 1995-2012 PMID25728651show ga The sensing of viral DNA is an essential step of cellular immune response to infections with DNA viruses. These human pathogens are spread worldwide, triggering a wide range of virus-induced diseases, and are associated with high levels of morbidity and mortality. Despite similarities between DNA molecules, mammalian cells have the remarkable ability to distinguish viral DNA from their own DNA. This detection is carried out by specialized antiviral proteins, called DNA sensors. These sensors bind to foreign DNA to activate downstream immune signaling pathways and alert neighboring cells by eliciting the expression of antiviral cytokines. The sensing of viral DNA was shown to occur both in the cytoplasm and nucleus of infected cells, disproving the notion that sensing occurred by simple spatial separation of viral and host DNA. A number of omic approaches, in particular mass spectrometry-based proteomic methods, have significantly contributed to the constantly evolving field of viral DNA sensing. Here, we review the impact of omic methods on the identification of viral DNA sensors, as well as on the characterization of mechanisms involved in host defense or viral immune evasion. äA Proteomics Perspective on Viral DNA Sensors in Host Defense and Vira(epmc).pdf DeepDyve Pubget Overpricing