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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Vasc+Interv+Radiol
2015 ; 26
(3
): 330-41
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Comparison of combination therapies in the management of hepatocellular
carcinoma: transarterial chemoembolization with radiofrequency ablation versus
microwave ablation
#MMPMID25534635
Ginsburg M
; Zivin SP
; Wroblewski K
; Doshi T
; Vasnani RJ
; Van Ha TG
J Vasc Interv Radiol
2015[Mar]; 26
(3
): 330-41
PMID25534635
show ga
PURPOSE: To compare retrospectively the outcomes and complications of
transcatheter arterial chemoembolization with drug-eluting embolic agents
combined with radiofrequency (RF) ablation or microwave (MW) ablation in
treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: From
2003-2011, 89 patients with HCC received a combination therapy-transcatheter
arterial chemoembolization plus RF ablation in 38 patients and transcatheter
arterial chemoembolization plus MW ablation in 51 patients. Local tumor response,
tumor progression-free survival (PFS), overall PFS, overall survival (OS), and
complications were compared. Overall PFS and OS were compared between the two
treatment groups in multivariate analysis controlling for Child-Pugh class,
Barcelona Clinic Liver Classification stage, and index tumor size. RESULTS:
Complete local tumor response was achieved in 37 (80.4%) of the tumors treated
with transcatheter arterial chemoembolization plus RF ablation and 49 (76.6%) of
the tumors treated with transcatheter arterial chemoembolization plus MW ablation
(P = .67). The median tumor PFS and overall PFS were 20.8 months and 9.3 months
(P = .72) for transarterial chemoembolization plus RF ablation and 21.8 months
and 9.2 months for transarterial chemoembolization plus MW ablation (P = .32).
The median OS of the transcatheter arterial chemoembolization plus RF ablation
group was 23.3 months, and the median OS of the transcatheter arterial
chemoembolization plus MW ablation group was 42.6 months, with no significant
difference in the survival experience between the two groups (log-rank test, P =
.10). In the multivariate analysis, Barcelona Clinic Liver Classification stage
was the only factor associated with overall PFS and OS. One patient in the
transcatheter arterial chemoembolization plus RF ablation cohort (3%) and two
patients in the transcatheter arterial chemoembolization plus MW ablation cohort
(4%) required prolonged hospitalization (< 48 h) for pain management after the
procedure (P = 1.00). CONCLUSIONS: Based on similar safety and efficacy outcomes,
both combination therapies, transcatheter arterial chemoembolization plus RF
ablation and transcatheter arterial chemoembolization plus MW ablation, are
effective treatments for HCC.