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2015 ; 7
(37
): 20649-56
Nephropedia Template TP
gab.com Text
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English Wikipedia
Hybrid Theranostic Platform for Second Near-IR Window Light Triggered Selective
Two-Photon Imaging and Photothermal Killing of Targeted Melanoma Cells
#MMPMID26327304
Tchounwou C
; Sinha SS
; Viraka Nellore BP
; Pramanik A
; Kanchanapally R
; Jones S
; Chavva SR
; Ray PC
ACS Appl Mater Interfaces
2015[Sep]; 7
(37
): 20649-56
PMID26327304
show ga
Despite advances in the medical field, even in the 21st century cancer is one of
the leading causes of death for men and women in the world. Since the second
near-infrared (NIR) biological window light between 950 and 1350 nm offers highly
efficient tissue penetration, the current article reports the development of
hybrid theranostic platform using anti-GD2 antibody attached gold nanoparticle
(GNP) conjugated, single-wall carbon nanotube (SWCNT) for second near-IR light
triggered selective imaging and efficient photothermal therapy of human melanoma
cancer cell. Reported results demonstrate that due to strong plasmon-coupling,
two-photon luminescence (TPL) intensity from theranostic GNP attached SWCNT
materials is 6 orders of magnitude higher than GNP or SWCNT alone. Experimental
and FDTD simulation data indicate that the huge enhancement of TPL intensity is
mainly due to strong resonance enhancement coupled with the stronger electric
field enhancement. Due to plasmon coupling, the theranostic material serves as a
local nanoantennae to enhance the photothermal capability via strong optical
energy absorption. Reported data show that theranostic SWCNT can be used for
selective two-photon imaging of melanoma UACC903 cell using 1100 nm light.
Photothermal killing experiment with 1.0 W/cm(2) 980 nm laser light demonstrates
that 100% of melanoma UACC903 cells can be killed using theranostic SWCNT bind
melanoma cells after just 8 min of exposure. These results demonstrate that due
to plasmon coupling, the theranostic GNP attached SWCNT material serves as a
two-photon imaging and photothermal source for cancer cells in biological window
II.