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10.1186/s13287-015-0232-9 http://scihub22266oqcxt.onion/10.1186/s13287-015-0232-9 C4668616!4668616 !26631254     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26631254 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cell+Res+Ther 2015 ; 6 (ä): 227 Nephropedia Template TP {{tp|p=26631254 |t=2015. Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles? |pdf=|usr=}}{{26631254 }} gab.com Text Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles JO: Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26631254 #FOAvip Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathological conditions. In recent years, a number of studies have demonstrated that EVs might hold remarkable potential in regenerative medicine by acting as therapeutically promising nanodrugs. Understanding their final impact on the biology of specific target cells as well as clarification of their overall therapeutic impact remains a matter of intense debate. Here we review the key principles of EVs in physiological and pathological conditions with a specific highlight on the most recently described mechanisms regulating some of the EV-mediated effects. First, we describe the current debates and the upcoming research on EVs as potential novel therapeutics in regenerative medicine, either as unmodified agents or as functionalized small carriers for targeted drug delivery. Moreover, we address a number of safety aspects and regulatory limitations related to the novel nature of EV-mediated therapeutic applications. Despite the emerging possibilities of EV treatments, these issues need to be overcome in order to allow their safe and successful application in future explorative clinical studies. Twit Text FOAVip Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles ????Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26631254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26631254 #FOAvip English Wikipedia <ref>{{Cite pmid|26631254 }}</ref> Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles? #MMPMID26631254 Fuster-Matanzo A ; Gessler F ; Leonardi T ; Iraci N ; Pluchino S Stem Cell Res Ther 2015[Dec]; 6 (ä): 227 PMID26631254 show ga Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathological conditions. In recent years, a number of studies have demonstrated that EVs might hold remarkable potential in regenerative medicine by acting as therapeutically promising nanodrugs. Understanding their final impact on the biology of specific target cells as well as clarification of their overall therapeutic impact remains a matter of intense debate. Here we review the key principles of EVs in physiological and pathological conditions with a specific highlight on the most recently described mechanisms regulating some of the EV-mediated effects. First, we describe the current debates and the upcoming research on EVs as potential novel therapeutics in regenerative medicine, either as unmodified agents or as functionalized small carriers for targeted drug delivery. Moreover, we address a number of safety aspects and regulatory limitations related to the novel nature of EV-mediated therapeutic applications. Despite the emerging possibilities of EV treatments, these issues need to be overcome in order to allow their safe and successful application in future explorative clinical studies. |*Extracellular Vesicles [MESH] |*Regenerative Medicine/trends [MESH] |Animals [MESH] |Clinical Trials as Topic [MESH] |Drug Carriers [MESH]Acellular approaches for regenerative medicine: on the verge of clinic(epmc).pdf DeepDyve Pubget Overpricing