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10.1038/srep17655 http://scihub22266oqcxt.onion/10.1038/srep17655 C4668385!4668385!26631972     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26631972|t=2015. Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo |pdf=|usr=}}{{26631972}} gab.com Text Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26631972 #FOAvip The Sec13 protein functions in various intracellular compartments including the nuclear pore complex, COPII-coated vesicles, and inside the nucleus as a transcription regulator. Here we developed a mouse model that expresses low levels of Sec13 (Sec13H/?) to assess its functions in vivo, as Sec13 knockout is lethal. These Sec13 mutant mice did not present gross defects in anatomy and physiology. However, the reduced levels of Sec13 in vivo yielded specific immunological defects. In particular, these Sec13 mutant mice showed low levels of MHC I and II expressed by macrophages, low levels of INF-? and IL-6 expressed by stimulated T cells, and low frequencies of splenic IFN-?+CD8+ T cells. In contrast, the levels of soluble and membrane-bound TGF-? as well as serum immunoglobulin production are high in these mice. Furthermore, frequencies of CD19+CD5-CD95+ and CD19+CD5-IL-4+ B cells were diminished in Sec13H/? mice. Upon stimulation or immunization, some of the defects observed in the naïve mutant mice were compensated. However, TGF-? expression remained high suggesting that Sec13 is a negative modulator of TGF-? expression and of its immunosuppressive functions on certain immune cells. In sum, Sec13 regulates specific expression of immune factors with key functions in inflammation. Twit Text FOAVip Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26631972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26631972 #FOAvip English Wikipedia <ref>{{Cite pmid|26631972}}</ref> Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo #MMPMID26631972 Moreira TG; Zhang L; Shaulov L; Harel A; Kuss SK; Williams J; Shelton J; Somatilaka B; Seemann J; Yang J; Sakthivel R; Nussenzveig DR; Faria AMC; Fontoura BMA Sci Rep 2015[]; 5 (ä): ä PMID26631972show ga The Sec13 protein functions in various intracellular compartments including the nuclear pore complex, COPII-coated vesicles, and inside the nucleus as a transcription regulator. Here we developed a mouse model that expresses low levels of Sec13 (Sec13H/?) to assess its functions in vivo, as Sec13 knockout is lethal. These Sec13 mutant mice did not present gross defects in anatomy and physiology. However, the reduced levels of Sec13 in vivo yielded specific immunological defects. In particular, these Sec13 mutant mice showed low levels of MHC I and II expressed by macrophages, low levels of INF-? and IL-6 expressed by stimulated T cells, and low frequencies of splenic IFN-?+CD8+ T cells. In contrast, the levels of soluble and membrane-bound TGF-? as well as serum immunoglobulin production are high in these mice. Furthermore, frequencies of CD19+CD5-CD95+ and CD19+CD5-IL-4+ B cells were diminished in Sec13H/? mice. Upon stimulation or immunization, some of the defects observed in the naïve mutant mice were compensated. However, TGF-? expression remained high suggesting that Sec13 is a negative modulator of TGF-? expression and of its immunosuppressive functions on certain immune cells. In sum, Sec13 regulates specific expression of immune factors with key functions in inflammation. äSec13 Regulates Expression of Specific Immune Factors Involved in Infl(epmc).pdf DeepDyve Pubget Overpricing