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10.1038/srep17658

http://scihub22266oqcxt.onion/10.1038/srep17658
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C4668371!4668371 !26631976
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suck abstract from ncbi


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pmid26631976
      Sci+Rep 2015 ; 5 (ä): 17658
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  • A network medicine approach to quantify distance between hereditary disease modules on the interactome #MMPMID26631976
  • Caniza H ; Romero AE ; Paccanaro A
  • Sci Rep 2015[Dec]; 5 (ä): 17658 PMID26631976 show ga
  • We introduce a MeSH-based method that accurately quantifies similarity between heritable diseases at molecular level. This method effectively brings together the existing information about diseases that is scattered across the vast corpus of biomedical literature. We prove that sets of MeSH terms provide a highly descriptive representation of heritable disease and that the structure of MeSH provides a natural way of combining individual MeSH vocabularies. We show that our measure can be used effectively in the prediction of candidate disease genes. We developed a web application to query more than 28.5 million relationships between 7,574 hereditary diseases (96% of OMIM) based on our similarity measure.
  • |*Genetic Diseases, Inborn/genetics [MESH]
  • |*Medical Subject Headings [MESH]
  • |Data Mining/methods [MESH]
  • |Genes [MESH]
  • |Humans [MESH]


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