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10.1038/srep17533 http://scihub22266oqcxt.onion/10.1038/srep17533 C4668355!4668355!26631983     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26631983|t=2015. The isolation and characterization of CTC subsets related to breast cancer dormancy |pdf=|usr=}}{{26631983}} gab.com Text The isolation and characterization of CTC subsets related to breast cancer dormancy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26631983 #FOAvip Uncovering CTCs phenotypes offer the promise to dissect their heterogeneity related to metastatic competence. CTC survival rates are highly variable and this can lead to many questions as yet unexplored properties of CTCs responsible for invasion and metastasis vs dormancy. We isolated CTC subsets from peripheral blood of patients diagnosed with or without breast cancer brain metastasis. CTC subsets were selected for EpCAM negativity but positivity for CD44+/CD24? stem cell signature; along with combinatorial expression of uPAR and int ?1, two markers directly implicated in breast cancer dormancy mechanisms. CTC subsets were cultured in vitro generating 3D CTC tumorspheres which were interrogated for biomarker profiling and biological characteristics. We identified proliferative and invasive properties of 3D CTC tumorspheres distinctive upon uPAR/int ?1 combinatorial expression. The molecular characterization of uPAR/int ?1 CTC subsets may enhance abilities to prospectively identify patients who may be at high risk of developing BCBM. Twit Text FOAVip The isolation and characterization of CTC subsets related to breast cancer dormancy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26631983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26631983 #FOAvip English Wikipedia <ref>{{Cite pmid|26631983}}</ref> The isolation and characterization of CTC subsets related to breast cancer dormancy #MMPMID26631983 Vishnoi M; Peddibhotla S; Yin W; T. Scamardo A; George GC; Hong DS; Marchetti D Sci Rep 2015[]; 5 (ä): ä PMID26631983show ga Uncovering CTCs phenotypes offer the promise to dissect their heterogeneity related to metastatic competence. CTC survival rates are highly variable and this can lead to many questions as yet unexplored properties of CTCs responsible for invasion and metastasis vs dormancy. We isolated CTC subsets from peripheral blood of patients diagnosed with or without breast cancer brain metastasis. CTC subsets were selected for EpCAM negativity but positivity for CD44+/CD24? stem cell signature; along with combinatorial expression of uPAR and int ?1, two markers directly implicated in breast cancer dormancy mechanisms. CTC subsets were cultured in vitro generating 3D CTC tumorspheres which were interrogated for biomarker profiling and biological characteristics. We identified proliferative and invasive properties of 3D CTC tumorspheres distinctive upon uPAR/int ?1 combinatorial expression. The molecular characterization of uPAR/int ?1 CTC subsets may enhance abilities to prospectively identify patients who may be at high risk of developing BCBM. äThe isolation and characterization of CTC subsets related to breast ca(epmc).pdf DeepDyve Pubget Overpricing